|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Preparation, Development and Evaluation of Spherical Poly Electrolyte Coacervates of Zidovudine Prepared by Emulsification Method |
| Authors Name: | Kotresh Yaligar , B.Madhulatha |
| Unique Id: | IJSDR2211059 |
| Published In: | Volume 7 Issue 11, November-2022 |
| Abstract: | The objective of the present work is to prepare spherical polyelectrolyte microcapsules of Zidovudine by a means of complex coacervation method in an emulsion system. Chitosan was used as the cationic polymer and sodium alginate and acacia as the anionic polymers. The two polymers were made to interact at a concentration of 2% and the coacervation was achieved at pH6.8. Glutaraldehyde was used as the cross linking agent. Microspheres were prepared in drug to polymer ratios of 0.5:1, 0.75:1 and 1:1. Microsphere suspension in arachis oil was prepared in ratio of 0.5:1. The emulsification used for microparticle formation allows the preparation of particles with spherical shape and narrow size distribution. The suspension was better than the dry product with respect to shape, drug content and also order of release, which was zero order for suspension whereas first order for the dried product. The drug from the suspension formulation was found to release over a period of 10hrs. The oily suspension provides a means of parenteral administration of Zidovudine, provided the particle size can be further reduced. This sustained release parenteral formulation of Zidovudine would be beneficial in comparison with the current intermittent oral dosage regimen. |
| Keywords: | Acacia, Chitosan, Sodium alginate, Zidovudine |
| Cite Article: | "Preparation, Development and Evaluation of Spherical Poly Electrolyte Coacervates of Zidovudine Prepared by Emulsification Method", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.357 - 372, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211059.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2211059 Registration ID:202499 Published In: Volume 7 Issue 11, November-2022 DOI (Digital Object Identifier): Page No: 357 - 372 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn