Comparative Study of The Effects of Serial Extracts of Solanum Aculeastrum Seeds on Prostatic Indices of Testosterone Propionate Induced Benign Prostatic Hyperplasia in Male Wistar Rats.

Joseph Anna Ubon , Monday Isaiah Akpanabiatu , Justina Ime Rufus Udotong , Udeme Ededem Okon

Solanum acculeastrum, BPH, Testosterone propionate, Finasteride, Wistar rats.

This study investigated the effect of serial extracts of Solanum aculeastrum seeds on testosterone propionate induced benign prostatic hyperplasia in adult male Wistar rats. Solanum aculeastrum is a tropical plant whose berries are widely used in folk medicine for the treatment of various inflammatory diseases. Finely ground Solanum aculeastrum seeds (1000 g) were extracted with hexane, chloroform, benzene, ethylacetate and ethanol respectively using serial exhaustive extraction technique. Male Wistar rats weighing 280 ± 20g were injected with 10 mg/kg body weight of Testosterone Propionate through intraperitoneal route for twenty eight days to induce BPH. The animals were divided into eight (8) groups of six (6) rats each. Group 1 (Normal control) was not induced with BPH and served as normal control, group 2 was induced and not treated and served as BPH control, group 3 (Finasteride control) was induced and received standard drug, finasteride while groups 4 (Hexane extract treated group), 5 (Chloroform extract treated group), 6 (Benzene extract treated group), 7 (Ethylacetate extract treated group) and 8 (Ethanol extract treated group) were induced and treated orally with 300 mg/kg body weight of hexane, chloroform, benzene, ethylacetate and ethanol extracts respectively for twenty eight days. The animals were sacrificed and blood collected through cardiac puncture. Biochemical studies were conducted using standard procedures. The result revealed that there were significant decreases in prostate weights, prostatic index, serum PSA, DHT, 5αRD2 and TNF-α levels in all the test groups compared to the BPH and finasteride control groups. Catalase activity was significantly increased in all the treatment groups compared to the BPH and finasteride control groups. All the extracts showed significant anti-BPH and antioxidant properties. These results suggest that serial extracts may be safe for use in the management of BPH. However anti-BPH activity was found to be solvent dependent and compared significantly with the standard drug. These findings support its therapeutic use by the herbalists in treating inflammatory diseases.

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"Comparative Study of The Effects of Serial Extracts of Solanum Aculeastrum Seeds on Prostatic Indices of Testosterone Propionate Induced Benign Prostatic Hyperplasia in Male Wistar Rats.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 7, page no.460 - 470, July-2022, Available :https://ijsdr.org/papers/IJSDR2207063.pdf

Volume 7 Issue 7, July-2022

Pages : 460 - 470

Paper Reg. ID: IJSDR_200969

Published Paper Id: IJSDR2207063

Downloads: 000347415

Research Area: Life Sciences 

Country: Uyo, Akwa Ibom, Nigeria

Published Paper PDF: https://ijsdr.org/papers/IJSDR2207063

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2207063

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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