Green approaches-synthesis of dihydropyrano [2,3-c] pyrazole by using eco friendly catalyst: review

Prajakta M. Shinde , Rita. D. Chakole , Manoj S. Charde

dihydropyrano(2,3-c)pyrazole, Magnetized dextrin,Nanoeggshell, ZN(ANA)Cl2, Molecular sieves, SO3H carbon powder, PTSA, Green chemistry, Multicomponent reaction.

Abstract : Magnetized dextrin, Nanoeggshell, ZN(ANA)Cl2, Molecular sieves, SO3H carbon powder, PTSA these novel naturally based catalyst are applied for the synthesis of dihydropyrno (2,3-c) pyrazole. Impelementation of green chemistry principle was evaluated for the synthesis of dihydropyrano(2,3-c) pyrazole derivative. Dihydropyrano(2,3-c) derivatives are synthesized by multicomponent condensation reactions by using components like aldehyde, hydrazinehydrate, ethylacetoacetate, malanonitrite.The principle affairs these procedure are mild condition, short reaction time, easy work up, high yield. reusability of catalysts and the absence of toxic organic solvent. Selected synthesized derivatives were used for Anti-inflammatory, Antidepressant, Antipyretic, Antifungal, Analgesic, Anti-HIV, Antimicrobial, Anticancer activity against four human cancer cell lines viz. melonoma cancer cell line(SK-MEL-2), breast cancer cell line (MDA-MB-231), Leukemia cancer cell line (K-562) and cervical cancer cell line (HeLa). ADME study of synthesized anticancer agent indicates good oral drug-like behaviour and non toxic nature.

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"Green approaches-synthesis of dihydropyrano [2,3-c] pyrazole by using eco friendly catalyst: review ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 6, page no.233 - 245, June-2022, Available :https://ijsdr.org/papers/IJSDR2206038.pdf

Volume 7 Issue 6, June-2022

Pages : 233 - 245

Paper Reg. ID: IJSDR_200658

Published Paper Id: IJSDR2206038

Downloads: 000347096

Research Area: Pharmacy

Country: sangli, Maharashtra, india

Published Paper PDF: https://ijsdr.org/papers/IJSDR2206038

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2206038

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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