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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Green approaches-synthesis of dihydropyrano [2,3-c] pyrazole by using eco friendly catalyst: review |
| Authors Name: | Prajakta M. Shinde , Rita. D. Chakole , Manoj S. Charde |
| Unique Id: | IJSDR2206038 |
| Published In: | Volume 7 Issue 6, June-2022 |
| Abstract: | Abstract : Magnetized dextrin, Nanoeggshell, ZN(ANA)Cl2, Molecular sieves, SO3H carbon powder, PTSA these novel naturally based catalyst are applied for the synthesis of dihydropyrno (2,3-c) pyrazole. Impelementation of green chemistry principle was evaluated for the synthesis of dihydropyrano(2,3-c) pyrazole derivative. Dihydropyrano(2,3-c) derivatives are synthesized by multicomponent condensation reactions by using components like aldehyde, hydrazinehydrate, ethylacetoacetate, malanonitrite.The principle affairs these procedure are mild condition, short reaction time, easy work up, high yield. reusability of catalysts and the absence of toxic organic solvent. Selected synthesized derivatives were used for Anti-inflammatory, Antidepressant, Antipyretic, Antifungal, Analgesic, Anti-HIV, Antimicrobial, Anticancer activity against four human cancer cell lines viz. melonoma cancer cell line(SK-MEL-2), breast cancer cell line (MDA-MB-231), Leukemia cancer cell line (K-562) and cervical cancer cell line (HeLa). ADME study of synthesized anticancer agent indicates good oral drug-like behaviour and non toxic nature. |
| Keywords: | dihydropyrano(2,3-c)pyrazole, Magnetized dextrin,Nanoeggshell, ZN(ANA)Cl2, Molecular sieves, SO3H carbon powder, PTSA, Green chemistry, Multicomponent reaction. |
| Cite Article: | "Green approaches-synthesis of dihydropyrano [2,3-c] pyrazole by using eco friendly catalyst: review ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 6, page no.233 - 245, June-2022, Available :http://www.ijsdr.org/papers/IJSDR2206038.pdf |
| Downloads: | 000346985 |
| Publication Details: | Published Paper ID: IJSDR2206038 Registration ID:200658 Published In: Volume 7 Issue 6, June-2022 DOI (Digital Object Identifier): Page No: 233 - 245 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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