Development and evaluation of In-Situ Gel.
ketorolac tromethamine (KT), Methylcellulose • Hydroxypropylmethylcellulose • In-situ gel • ORS
The ophthalmic in-situ gels now days manage a palpable sustained drug delivery in various ophthalmic diseases. The formulation of in-situ gels for eye which carries the advantages like easy for administration, decreases frequency of dose and better patient compliance. The formation of in-situ gels depends on phase change system or sol-gel transition system. The formulation approaches like temperature intonation, pH change and presence of ions from which the drug gets released during a sustained and controlled manner are used for in-situ gels. Various polymers that are used for the formulation of in-situ gels include chitosan, Pluronic F-127, poly-caprolactone, gellan gum, algin , xyloglucan, pectin etc.The development of thermo-sensitive in-situ gels for in-vitro evaluation of ophthalmic delivery systems of Acular (KT), supported methylcellulose (MC) together with hydroxypropylmethyl cellulose (HPMC). The gel temperature of 1% MC solution was observed at 60°C. It was found that 6% oral rehydration salt without dextrose (ORS) was capable to decrease the gel temperature below physiological temperature. HPMC was added to extend viscosity and drug release time. The results indicated an outsized increase in viscosity at 37°C with addition of HPMC whch provided sustained release of the drug over a 4h period. From in-vitro release studies, it might be concluded that the developed systems were thus a far better alternative to standard eye drops.
"Development and evaluation of In-Situ Gel.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 8, page no.118 - 121, August-2021, Available :https://ijsdr.org/papers/IJSDR2108020.pdf
Volume 6
Issue 8,
August-2021
Pages : 118 - 121
Paper Reg. ID: IJSDR_193593
Published Paper Id: IJSDR2108020
Downloads: 000347301
Research Area: Pharmacy
Country: dPune, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
