Evaluation of CNS and Behavioral Activity of Evolvulus Nummularius Plant in Experimental Animal Models

Sunita Jaiswal , Dr. Ankit H. Merai , Dr. Chirag Desai , Dr. Arindam Paul

Central nervous system, Depressant, Extract, Sedative, Rotarod, Actophotometer, Y-maze, E. Nummularius

Aim: To evaluate Central Nervous System (CNS) and behavioral activity of EvolvulusNummularius plant in experimental animal models. Methods: Experimental Animals (Rats) were acclimatized to laboratory conditions& were divided into four groups each containing 6 animals. Animals were divided into Control, standard, test-1, test-2 groups which receive 1% gum acacia, diazepam (10mg/kg), ethanolic extract of EvolvulusNummularius (200mg/kg) and (400mg/kg) respectively. Ethanolic extract of EvolvulusNummularius was used to examine CNS activity using experimental models like phenobarbitone sodium-induced sleeping time to evaluate sedative activity, Y-maze to evaluate exploratory behavior, Rotarod to evaluate muscle relaxant activity, and Actophotometer for locomotor activity. Result & Discussion: Acute toxicity study revealed that no toxicity and mortality were seen and LD50> 2000mg/kg of extract. It is observed that no abnormality is seen during the assessment of the behavioral profile. Preliminary phytochemical analysis reveals the presence of chemical constituents like alkaloids, ergoline alkaloids, flavonoids, saponins, glycosides, anthraquinones, etc. which may responsible for psychopharmacological action. It is clear that plant extract significantly increases the sleeping latency and duration of sleep in rats when compared with control. It is observed that the extract showed a significant reduction in exploratory behavior of rats in y-maze when compared to control. In addition, the extract showed a marked reduction in muscle relaxant and locomotor activity of rats in Rotarod and Actophotometer respectively when compared with a control group. Conclusion: Based on the result of the present study, it can be concluded that doses of 200mg/kg and 400mg/kg of ethanolic extract of aerial parts of EvolvulusNummularius possess CNS depressant activity.

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"Evaluation of CNS and Behavioral Activity of Evolvulus Nummularius Plant in Experimental Animal Models", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 5, page no.371 - 379, May-2021, Available :https://ijsdr.org/papers/IJSDR2105057.pdf

Volume 6 Issue 5, May-2021

Pages : 371 - 379

Paper Reg. ID: IJSDR_193345

Published Paper Id: IJSDR2105057

Downloads: 000347233

Research Area: Pharmacy

Country: Vapi, Gujarat, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2105057

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2105057

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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