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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Evaluation of CNS and Behavioral Activity of Evolvulus Nummularius Plant in Experimental Animal Models |
| Authors Name: | Sunita Jaiswal , Dr. Ankit H. Merai , Dr. Chirag Desai , Dr. Arindam Paul |
| Unique Id: | IJSDR2105057 |
| Published In: | Volume 6 Issue 5, May-2021 |
| Abstract: | Aim: To evaluate Central Nervous System (CNS) and behavioral activity of EvolvulusNummularius plant in experimental animal models. Methods: Experimental Animals (Rats) were acclimatized to laboratory conditions& were divided into four groups each containing 6 animals. Animals were divided into Control, standard, test-1, test-2 groups which receive 1% gum acacia, diazepam (10mg/kg), ethanolic extract of EvolvulusNummularius (200mg/kg) and (400mg/kg) respectively. Ethanolic extract of EvolvulusNummularius was used to examine CNS activity using experimental models like phenobarbitone sodium-induced sleeping time to evaluate sedative activity, Y-maze to evaluate exploratory behavior, Rotarod to evaluate muscle relaxant activity, and Actophotometer for locomotor activity. Result & Discussion: Acute toxicity study revealed that no toxicity and mortality were seen and LD50> 2000mg/kg of extract. It is observed that no abnormality is seen during the assessment of the behavioral profile. Preliminary phytochemical analysis reveals the presence of chemical constituents like alkaloids, ergoline alkaloids, flavonoids, saponins, glycosides, anthraquinones, etc. which may responsible for psychopharmacological action. It is clear that plant extract significantly increases the sleeping latency and duration of sleep in rats when compared with control. It is observed that the extract showed a significant reduction in exploratory behavior of rats in y-maze when compared to control. In addition, the extract showed a marked reduction in muscle relaxant and locomotor activity of rats in Rotarod and Actophotometer respectively when compared with a control group. Conclusion: Based on the result of the present study, it can be concluded that doses of 200mg/kg and 400mg/kg of ethanolic extract of aerial parts of EvolvulusNummularius possess CNS depressant activity. |
| Keywords: | Central nervous system, Depressant, Extract, Sedative, Rotarod, Actophotometer, Y-maze, E. Nummularius |
| Cite Article: | "Evaluation of CNS and Behavioral Activity of Evolvulus Nummularius Plant in Experimental Animal Models", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 5, page no.371 - 379, May-2021, Available :http://www.ijsdr.org/papers/IJSDR2105057.pdf |
| Downloads: | 000337073 |
| Publication Details: | Published Paper ID: IJSDR2105057 Registration ID:193345 Published In: Volume 6 Issue 5, May-2021 DOI (Digital Object Identifier): Page No: 371 - 379 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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