INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Drug penetration in necrotised tissue of periodontal lesion - A Review
Authors Name:
Lakshya Rani .S
, Gopinath.P
Unique Id:
IJSDR2105003
Published In:
Volume 6 Issue 5, May-2021
Abstract:
Periodontitis is an inflammatory disease of gums involving the degeneration of periodontal ligaments, creation of periodontal pocket and resorption of alveolar bone, resulting in the disruption of the support structure of teeth. According to WHO, 10–15% of the global population suffers from severe periodontitis. The disease results from the growth of a diverse microflora (especially anaerobes) in the pockets and release of toxins, enzymes and stimulation of body’s immune response. Various local or systemic approaches were used for an effective treatment of periodontitis. Currently, controlled local drug delivery approach is more favorable as compared to systemic approach because it mainly focuses on improving the therapeutic outcomes by achieving factors like site-specific delivery, low dose requirement, bypass of firstpass metabolism, reduction in gastrointestinal side effects and decrease in dosing frequency. Overall it provides a safe and effective mode of treatment, which enhances patient compliance. Complete eradication of the organisms from the sites was not achieved by using various surgical and mechanical treatments. So a number of polymer-based delivery systems like fibers, films, chips, strips, microparticles, nanoparticles and nanofibers made from a variety of natural and synthetic materials have been successfully tested to deliver a variety of drugs. These systems are biocompatible and biodegradable, completely fill the pockets, and have strong retention on the target site due to excellent mucoadhesion properties. The review summarizes various available drugs and penetration level of drugs in the treatment of periodontitis.
Keywords:
Periodontitis, microparticles, nanofibres, mucoadhesion, drug delivery system
Cite Article:
"Drug penetration in necrotised tissue of periodontal lesion - A Review ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 5, page no.11 - 15, May-2021, Available :http://www.ijsdr.org/papers/IJSDR2105003.pdf
Downloads:
000336257
Publication Details:
Published Paper ID: IJSDR2105003
Registration ID:193234
Published In: Volume 6 Issue 5, May-2021
DOI (Digital Object Identifier):
Page No: 11 - 15
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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