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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A review on self- micro emulsifying drug delivery systems |
| Authors Name: | G. Lakshmi Devi , Nur alom mondal , Mangali Mahender , Koruboyina Shiva , Jvc sharma |
| Unique Id: | IJSDR2102035 |
| Published In: | Volume 6 Issue 2, February-2021 |
| Abstract: | Oral route has always been preferred route for formulators and has dominated over other routes of administrations. However this preferred route is limited to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Improving oral bioavailability of low poorly water soluble drugs using self-emulsifying drug delivery systems (SEDDS) possess significant potential. Oral bioavailability of hydrophobic drugs can be improved using SEDDS, and appears most promising. Their dispersion in gastro intestinal (GI) fluid after administration forms micro or nano emulsified drug which gets easily absorbed through lymphatic pathways bypassing the hepatic first pass metabolism. SMEDDS are isotropic mixtures of oil,surfactant,co-surfactant and drug with a unique ability to form fine oil in water microemulsion upon mild agitation following dilution with aqueous phase. This article gives an overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble drugs. |
| Keywords: | SEDDS, SMEDDS, low bioavailability and microemulsions |
| Cite Article: | "A review on self- micro emulsifying drug delivery systems", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 2, page no.242 - 252, February-2021, Available :http://www.ijsdr.org/papers/IJSDR2102035.pdf |
| Downloads: | 000337068 |
| Publication Details: | Published Paper ID: IJSDR2102035 Registration ID:192919 Published In: Volume 6 Issue 2, February-2021 DOI (Digital Object Identifier): Page No: 242 - 252 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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