A review on self- micro emulsifying drug delivery systems

G. Lakshmi Devi , Nur alom mondal , Mangali Mahender , Koruboyina Shiva , Jvc sharma

SEDDS, SMEDDS, low bioavailability and microemulsions

Oral route has always been preferred route for formulators and has dominated over other routes of administrations. However this preferred route is limited to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Improving oral bioavailability of low poorly water soluble drugs using self-emulsifying drug delivery systems (SEDDS) possess significant potential. Oral bioavailability of hydrophobic drugs can be improved using SEDDS, and appears most promising. Their dispersion in gastro intestinal (GI) fluid after administration forms micro or nano emulsified drug which gets easily absorbed through lymphatic pathways bypassing the hepatic first pass metabolism. SMEDDS are isotropic mixtures of oil,surfactant,co-surfactant and drug with a unique ability to form fine oil in water microemulsion upon mild agitation following dilution with aqueous phase. This article gives an overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble drugs.

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"A review on self- micro emulsifying drug delivery systems", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 2, page no.242 - 252, February-2021, Available :https://ijsdr.org/papers/IJSDR2102035.pdf

Volume 6 Issue 2, February-2021

Pages : 242 - 252

Paper Reg. ID: IJSDR_192919

Published Paper Id: IJSDR2102035

Downloads: 000347426

Research Area: Pharmacy

Country: HYDERABAD, TELANGANA, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2102035

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2102035

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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