International Journal of Scientific Development and Research - IJSDR
(An International Open Access Journal)

Issue: July 2021

Volume 6 | Issue 7

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Authors Name: Jyoti Saxena , Pranshu Tangri , Amrita Bisht , Surbhi Verma
Unique Id: IJSDR2102002
Published In: Volume 6 Issue 2, February-2021
Abstract: The aim of the study was to Development and Evaluation of Miconazole Nitrate entrapped polymeric nanoparticles by nanoprecipitation method using different drug and polymer ratio. Miconazole Nitrate is an antifungal drug with a poor aqueous solubility, which requires the development of new delivery systems to improve its therapeutic effects. Fungal infections are caused by microscopic organisms that invade the epithelial tissue. The drug nanoparticles were prepared using chitosan and Eudragit RS 100 as drug loading polymer. These nanoparticles can effectively direct drug delivery to specific targets and improve drug stability and controlled drug release. Nanoparticles of different ratios were formulated and analyzed for drug content, entrapment efficiency, particle size, zeta potential and in vitro drug release studies. Acetone : Water (1:1) co-solvent system is selected for preparing Miconazole Nitrate loaded nanoparticles using different polymers. Different formulations of nanoparticles were evaluated by using different parameters such as pre & post- formulation studies. F1 & F10 were showed the best drug release within 12 hrs.
Keywords: Nanoparticles, nanoprecipitation method, Miconazole Nitrate and Topical drug delivery system.
Cite Article: "DEVELOPMENT AND EVALUATION OF MICONAZOLE NITRATE ENTRAPPED POLYMERIC NANOPARTICLES", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 2, page no.15 - 21, February-2021, Available :http://www.ijsdr.org/papers/IJSDR2102002.pdf
Downloads: 00025297
Publication Details: Published Paper ID: IJSDR2102002
Registration ID:192870
Published In: Volume 6 Issue 2, February-2021
DOI (Digital Object Identifier):
Page No: 15 - 21
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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