DEVELOPMENT AND EVALUATION OF MICONAZOLE NITRATE ENTRAPPED POLYMERIC NANOPARTICLES

Jyoti Saxena , Pranshu Tangri , Amrita Bisht , Surbhi Verma

Nanoparticles, nanoprecipitation method, Miconazole Nitrate and Topical drug delivery system.

The aim of the study was to Development and Evaluation of Miconazole Nitrate entrapped polymeric nanoparticles by nanoprecipitation method using different drug and polymer ratio. Miconazole Nitrate is an antifungal drug with a poor aqueous solubility, which requires the development of new delivery systems to improve its therapeutic effects. Fungal infections are caused by microscopic organisms that invade the epithelial tissue. The drug nanoparticles were prepared using chitosan and Eudragit RS 100 as drug loading polymer. These nanoparticles can effectively direct drug delivery to specific targets and improve drug stability and controlled drug release. Nanoparticles of different ratios were formulated and analyzed for drug content, entrapment efficiency, particle size, zeta potential and in vitro drug release studies. Acetone : Water (1:1) co-solvent system is selected for preparing Miconazole Nitrate loaded nanoparticles using different polymers. Different formulations of nanoparticles were evaluated by using different parameters such as pre & post- formulation studies. F1 & F10 were showed the best drug release within 12 hrs.

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"DEVELOPMENT AND EVALUATION OF MICONAZOLE NITRATE ENTRAPPED POLYMERIC NANOPARTICLES", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 2, page no.15 - 21, February-2021, Available :https://ijsdr.org/papers/IJSDR2102002.pdf

Volume 6 Issue 2, February-2021

Pages : 15 - 21

Paper Reg. ID: IJSDR_192870

Published Paper Id: IJSDR2102002

Downloads: 000347387

Research Area: Pharmacy

Country: Dehradun, Uttarakhand, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2102002

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2102002

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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