Welcome to IJSDR UGC CARE norms ugc approved journal norms IJRTI Research Journal | ISSN : 2455-2631
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.15 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

Issue: June 2023

Volume 8 | Issue 6

Impact factor: 8.15

Click Here For more Info

Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter

Copyright Infringement Claims
Indexing Partner
Published Paper Details
Paper Title: Chronopharmacology: A Great Future for the Medicines
Authors Name: Amol A. Patil , Manohar D. Kengar , Suhas A. Mane , Sujit A. Wagmare , Dnyaneshwar M. Nirmale
Unique Id: IJSDR2002048
Published In: Volume 5 Issue 2, February-2020
Abstract: Chronopharmacology is helpful to solve problems of drug dose optimization i.e. improve the efficacy or reduce undesired effects. In the human the metabolic fate of a pharmacological agent is not constant as a function of a time. Thus during metabolic it is much useful chronobiological approach of pharmacological phenomena it includes a lesser risk of errors. Chronobiology is the branch of science which examines periodic phenomenon in living organisms and their adaptation to biological rhythm. These biological rhythms can be yearly, monthly, daily or more frequent. Daily (24hr) rhythms are called as CR. Chronopharmacology is the branch of science which take into account the influence of time. It is concerned with the effects of drug upon the timing of biological events and rhythms and the relation of biological timing and endogenous periodicities to the effect of drugs. It further deals with chronotherapeutics, chronokinetics, and chronotoxicity. The circadian rhythms in mammals are maintained and regulated by the master clock in brain called as Supra chiasmatic nucleus (SCN) present inhypothalamus. Circadian rhythms deal with the cyclic changes occurring in day and night which depends on absence and presence of light. When the light falls on the retina, the light sensitive ganglion cells act as receptors and sends signals to SCN through retinohypothalamic tracts. SCN either directly by influencing pineal gland which releases melatonin or indirectly by influencing autonomic nervous system regulates different physiological activities. Biological rhythms were affect on various system . Circadian rhythms are also exhibited by many diseases. Some drugs in absorption (A), distribution (D), metabolism (M) and excretion (E) in relation to time. During the CR hanges in ADME and takes into account the influence of time of administration on these different processes is called as chronopharmacokinetics either chronokinetics.
Keywords: Chronopharmacology, Chronopharmacokinetics, Circadian rhythms (CR), Suprachiasmatic nucleus, Chronotherapeutics, Pulsatile drug delivery system.
Cite Article: "Chronopharmacology: A Great Future for the Medicines", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 2, page no.284 - 293, February-2020, Available :http://www.ijsdr.org/papers/IJSDR2002048.pdf
Downloads: 000223233
Publication Details: Published Paper ID: IJSDR2002048
Registration ID:191370
Published In: Volume 5 Issue 2, February-2020
DOI (Digital Object Identifier):
Page No: 284 - 293
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

Click Here to Download This Article

Article Preview

Click here for Article Preview

Major Indexing from www.ijsdr.org
Google Scholar ResearcherID Thomson Reuters Mendeley : reference manager Academia.edu
arXiv.org : cornell university library Research Gate CiteSeerX DOAJ : Directory of Open Access Journals
DRJI Index Copernicus International Scribd DocStoc

Track Paper
Important Links
Conference Proposal
DOI (A digital object identifier)

Providing A digital object identifier by DOI
How to GET DOI and Hard Copy Related
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Creative Commons License
This material is Open Knowledge
This material is Open Data
This material is Open Content
Social Media

Indexing Partner