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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF GRAZOPREVIR AND ELBASVIR BY RP-HPLC METHOD |
| Authors Name: | MOKARA LAXMI PRIYA , M.LAKSHMI PRASANNA , G SIREESHA |
| Unique Id: | IJSDR191969 |
| Published In: | Volume 5 Issue 6, June-2020 |
| Abstract: | A simple, Accurate, precise method was developed for the simultaneous estimation of the Grazoprevir and Elbasvir in Tablet dosage form. Chromatogram was run through BDS C8 (150mm 4.6mm, 5µ). Mobile phase containing Buffer Acetonitrile and methanol in the ratio of 45:55 was pumped through column at a flow rate of 1.0 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Grazoprevir and Elbasvir was 260nm. Retention time of Grazoprevir and Elbasvir were found to be 2.164min and 3.297min. %RSD of the Grazoprevir and Elbasvir were found to be 0.4 and 0.5 respectively. %Recover was Obtained as 99.99% and 99.58% for Grazoprevir and Elbasvir. LOD, LOQ values were obtained from regression equations of Grazoprevir and Elbasvir were 0.30ppm, 0.92ppm and 0.21ppm, 0.63ppm respectively. Regression equation of Grazoprevir y= 12298x+1919 and of Elbasvir is y = 20859x + 2050. Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries |
| Keywords: | GRAZOPREVIR ELBASVIR RP-HPLC |
| Cite Article: | "METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF GRAZOPREVIR AND ELBASVIR BY RP-HPLC METHOD", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 6, page no.1 - 116, June-2020, Available :http://www.ijsdr.org/papers/IJSDR191969.pdf |
| Downloads: | 000314591 |
| Publication Details: | Published Paper ID: IJSDR191969 Registration ID:191969 Published In: Volume 5 Issue 6, June-2020 DOI (Digital Object Identifier): Page No: 1 - 116 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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