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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Paper Title: DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR SIMULTANEOUS ESTIMATION OF CEFTOLOZANE AND TAZOBACTUM BY USING RP-HPLC
Authors Name: Bangaruthalli Jagirapu , M.Naga Bharathi , N.Hemalatha , R. sailaja Kumar , Kusumapriya.N
Unique Id: IJSDR1901051
Published In: Volume 4 Issue 1, January-2019
Abstract: A simple, Accurate, precise method was developed for the simultaneous estimation of Ceftolozane and Tazobactum in Pharmaceutical dosage form. Chromatogram was run through Std ODS 250mm x 4.6 mm, 5m. Mobile phase containing Buffer (Ortho Phosphoric Acid), Acetonitrile in the ratio of (60:40) was pumped through column at a flow rate of 1ml/min. Temperature was maintained at 30°C. Optimized wavelength for Ceftolozane and Tazobactum was 210nm. Retention times of Ceftolozane and Tazobactum were found to be 2.315 min and 3.685 min. % RSD of the Ceftolozane and Tazobactum were and found to be 0.35 and 0.37 respectively. % Recover was Obtained as 100.14% and 99.57% for Ceftolozane and Tazobactum respectively. LOD, LOQ values obtained from regression equations of Ceftolozane and Tazobactum were 0.02, 0.03 and 0.07, 0.08, respectively. The method developed was simple and economical that can be adopted in regular Quality control test in Industries.
Keywords: Cefoperazone, Tazobactam , Ortho phosphoric acid, Acetonitrile , ICH guidelines, Validation.
Cite Article: "DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR SIMULTANEOUS ESTIMATION OF CEFTOLOZANE AND TAZOBACTUM BY USING RP-HPLC", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.4, Issue 1, page no.292 - 299, January-2019, Available :http://www.ijsdr.org/papers/IJSDR1901051.pdf
Downloads: 000336257
Publication Details: Published Paper ID: IJSDR1901051
Registration ID:190044
Published In: Volume 4 Issue 1, January-2019
DOI (Digital Object Identifier):
Page No: 292 - 299
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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