Bioinformatics Analysis of BDNF-TrkB Interactions to Identify Nerve growth factor and Neurotrophin-3 as Agonist of TrkB Helpful in Cell Survival Signaling Pathways of Type 2 Diabetic Retinopathy

Vaibhav Singh , Anjali Dwivedi , Archana Tiwari

Type 2 Diabetic retinopathy, Brain-derived neurotrophic factor, Tropomyosin-related kinase B, Nerve growth factor, Neurotrophin-3

Type 2 Diabetic Retinopathy is a communal cause of visual damage in the world and it is actually blinding complication of diabetes that damages the eye's retina. Type 2 Diabetic retinopathy is a complication of diabetes that distresses the blood vessels of the retina. Growth of new blood vessels, known as proliferative retinopathy, may lead to blindness through hemorrhage and scarring. A worsening of retinal blood vessels producing loss of blood vessels and leakage into the retina is known as maculopathy and leads to visual impairment and may progress to blindness. Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function. In this research, NTF3, NGF interactions with TrkB has been done as NTF3 and NGF acts as agonist for TrkB, which may help in retinal cell survival which would in turn help in controlling Type 2 Diabetic Retinopathy.

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"Bioinformatics Analysis of BDNF-TrkB Interactions to Identify Nerve growth factor and Neurotrophin-3 as Agonist of TrkB Helpful in Cell Survival Signaling Pathways of Type 2 Diabetic Retinopathy", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.3, Issue 5, page no.645 - 652, May-2018, Available :https://ijsdr.org/papers/IJSDR1805098.pdf

Volume 3 Issue 5, May-2018

Pages : 645 - 652

Paper Reg. ID: IJSDR_180350

Published Paper Id: IJSDR1805098

Downloads: 000347443

Research Area: Engineering

Country: Bhopal, Madhya Pradesh, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR1805098

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR1805098

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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