PHENOBARBITONE TOXICITY : A RARE ADVERSE DRUG REACTION CASE REPORT EMPHASIZING PATIENT CARE AND CLINICAL MANAGEMENT

Vasantha priya , Saheena C , Adivesha S A , Dr. Syed Mohammed Hussaini

Barbiturate toxicity, Central Nervous System depression, Chronic therapeutic use, Phenobarbitone, Seizure disorder.

Phenobarbitone is a long-acting barbiturate commonly used in the management of seizure disorders, particularly in resource-limited settings due to its affordability and efficacy. However, its narrow therapeutic index and prolonged half-life predispose patients to potential toxicity, even during chronic therapeutic use. We report a case of a 28-year-old female with a known seizure disorder on long-term phenobarbitone therapy who presented with altered sensorium and reduced responsiveness. Clinical assessment revealed moderate central nervous system depression (E2V4M4) with stable vital parameters. Laboratory evaluation demonstrated severe microcytic hypochromic anemia, and serum phenobarbitone levels were elevated at 59 µg/mL, exceeding the toxic range (>40 µg/mL). The patient was managed with prompt supportive care, monitoring and modification of antiepileptic therapy, leading to gradual clinical improvement without major cardiopulmonary complications. This case emphasizes the importance of therapeutic drug monitoring, periodic laboratory surveillance, and early recognition of toxicity in patients receiving long-term phenobarbitone therapy to ensure safe and effective seizure management.

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"PHENOBARBITONE TOXICITY : A RARE ADVERSE DRUG REACTION CASE REPORT EMPHASIZING PATIENT CARE AND CLINICAL MANAGEMENT", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.11, Issue 4, page no.b198-b207, April-2026, Available :https://ijsdr.org/papers/IJSDR2604161.pdf

Volume 11 Issue 4, April-2026

Pages : b198-b207

Paper Reg. ID: IJSDR_307748

Published Paper Id: IJSDR2604161

Downloads: 000203

Research Area: Pharmacy All

Country: Toranagallu/ Ballari, Karnataka, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2604161

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2604161

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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