Molecular Mechanisms and Pathology of Rat Models in Diabetic Neuropathy: A Comprehensive Review

Malligeshwaran N , Lokesh B , Srinidhi R

Rat models, molecular mechanisms, pathology, hyperglycemia, diabetic neuropathy.

Rat models have emerged as indispensable assets in biomedical research due to their physiological and genetic similarities to humans, making them invaluable in unraveling the molecular intricacies of numerous diseases. Across a spectrum of fields, including neurology, oncology, cardiovascular, and metabolic disorders, rat models have offered profound insights into disease pathogenesis. In neurology, rat models have been pivotal in deciphering the mechanisms underlying neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Through the manipulation of specific genes or induction of pathological conditions, researchers have elucidated molecular pathways involved in disease initiation and progression. Similarly, in oncology, rat models have facilitated the study of tumor development, metastasis, and responses to therapy. By introducing genetic alterations or carcinogens, researchers have replicated various stages of cancer, enabling the evaluation of potential therapeutic targets and treatment strategies. Cardiovascular research has also greatly benefited from rat models, with studies focusing on hypertension, heart failure, and atherosclerosis. These models have elucidated pathways involved in vascular dysfunction, myocardial remodeling, and cardiac hypertrophy, contributing to the development of novel therapeutic interventions. Furthermore, in metabolic disorders such as diabetes and obesity, rat models have provided invaluable insights into insulin resistance, glucose metabolism, and adipose tissue biology, paving the way for the development of new pharmacological agents and lifestyle interventions.

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"Molecular Mechanisms and Pathology of Rat Models in Diabetic Neuropathy: A Comprehensive Review", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 3, page no.992 - 996, March-2024, Available :https://ijsdr.org/papers/IJSDR2403138.pdf

Volume 9 Issue 3, March-2024

Pages : 992 - 996

Paper Reg. ID: IJSDR_210590

Published Paper Id: IJSDR2403138

Downloads: 000347084

Research Area: Pharmacy

Country: Salem, Tamilnadu, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2403138

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2403138

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition