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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Molecular Mechanisms and Pathology of Rat Models in Diabetic Neuropathy: A Comprehensive Review |
| Authors Name: | Malligeshwaran N , Lokesh B , Srinidhi R |
| Unique Id: | IJSDR2403138 |
| Published In: | Volume 9 Issue 3, March-2024 |
| Abstract: | Rat models have emerged as indispensable assets in biomedical research due to their physiological and genetic similarities to humans, making them invaluable in unraveling the molecular intricacies of numerous diseases. Across a spectrum of fields, including neurology, oncology, cardiovascular, and metabolic disorders, rat models have offered profound insights into disease pathogenesis. In neurology, rat models have been pivotal in deciphering the mechanisms underlying neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Through the manipulation of specific genes or induction of pathological conditions, researchers have elucidated molecular pathways involved in disease initiation and progression. Similarly, in oncology, rat models have facilitated the study of tumor development, metastasis, and responses to therapy. By introducing genetic alterations or carcinogens, researchers have replicated various stages of cancer, enabling the evaluation of potential therapeutic targets and treatment strategies. Cardiovascular research has also greatly benefited from rat models, with studies focusing on hypertension, heart failure, and atherosclerosis. These models have elucidated pathways involved in vascular dysfunction, myocardial remodeling, and cardiac hypertrophy, contributing to the development of novel therapeutic interventions. Furthermore, in metabolic disorders such as diabetes and obesity, rat models have provided invaluable insights into insulin resistance, glucose metabolism, and adipose tissue biology, paving the way for the development of new pharmacological agents and lifestyle interventions. |
| Keywords: | Rat models, molecular mechanisms, pathology, hyperglycemia, diabetic neuropathy. |
| Cite Article: | "Molecular Mechanisms and Pathology of Rat Models in Diabetic Neuropathy: A Comprehensive Review", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 3, page no.992 - 996, March-2024, Available :http://www.ijsdr.org/papers/IJSDR2403138.pdf |
| Downloads: | 000337361 |
| Publication Details: | Published Paper ID: IJSDR2403138 Registration ID:210590 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: 992 - 996 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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