|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | PRELIMINARY PHYTOCHEMICAL ANALYSIS, IN VITRO ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITY OF AMMANNIA BACCIFEARA |
| Authors Name: | Putta Arun |
| Unique Id: | IJSDR2403084 |
| Published In: | Volume 9 Issue 3, March-2024 |
| Abstract: | The phytochemical screening of the hydroalcoholic extract of Ammannia baccifera. (Leaf) powder revealed the presence of alkaloids, carbohydrates, sterols, saponins, tannins and phenolic compound, flavonoids, protein and free aminoacid, terpenoids, mucilage, betacyanin, quinone, phlobatannins, carotenoids. It shows the absence of anthraquinone glycosides, cardiac glycoside, fixed oil, anthocyanin, lecoanthocyanin, emodin, gum, resins, volatile oil. A study has reported that the flavonoids exert membrane stabilizing effect on lysosomes both invitro and invivo in experimental animals. Another report has suggested that tannins and saponins have the ability to bind cations and other biomolecules and are able to stabilize the erythrocyte membrane. HAEAB extract is highly potent on human erythrocyte and thus adequately protecting it against heat and hypotonicity induced lysis. The inhibitory concentration (IC50) of Ammannia baccifera. (Leaf) in HRBC membrane stabilization study is found to be 69µg/ml in comparison with diclofenac sodium 57µg/ml. It showed mild anti-inflammatory activity. The phytochemical analysis showed that the HRBC has flavonoids and tannins. Hence the HRBC membrane stabilizing capacity may be due to the presence of the above mentioned constituents which will prevent the oxidation of haemoglobin and also due to its antioxidant property. The principle involved is the inhibition of protein denaturation. Denaturation of protein was found to be one of the causes of rheumatoid arthritis. In rheumatoid arthritis, the production of autoantigen may be due to protein denaturation which involves the alteration of electrostatic hydrogen, hydrophobic and disulphide bonding. The protein used in this study is bovine serum albumin. Denaturation of protein is carried out by heating. The aim of this activity is to inhibit denaturation and to exhibit protective effect against rheumatoid arthritis. The inhibitory concentration (IC50) of Ammannia baccifera. (Leaf) in Protein denaturation is found to be 17µg/ml in comparison with diclofenac sodium 14µg/ml. It showed moderate anti-arthritic activity. The inhibition of protein denaturation by HAEAB may be due to the presence of phenolic compounds, flavonoids and tannins. |
| Keywords: | Preliminary Phytochemical Analysis, In Vitro Anti-Arthritic, Anti-Inflammatory Activity, Ammannia Baccifeara |
| Cite Article: | "PRELIMINARY PHYTOCHEMICAL ANALYSIS, IN VITRO ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITY OF AMMANNIA BACCIFEARA", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 3, page no.556 - 565, March-2024, Available :http://www.ijsdr.org/papers/IJSDR2403084.pdf |
| Downloads: | 000337362 |
| Publication Details: | Published Paper ID: IJSDR2403084 Registration ID:210421 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: 556 - 565 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn