Structure based Drug Design

Suzain Zulfikar Shaikh , Mr.A.N.Khadse.

Keywords: Structure- based drug discovery, Tools used for SBDD, Virtual screening, Molecular docking, Advances in SBDD.

The use of structure-based drug design, as opposed to the conventional approach, is becoming increasingly important for speedier and more valuable lead discovery. Research in the fields of structural, proteomic, and genomics has opened up countless new avenues for future drug discovery. Since rational, structure-based drug design employs the knowledge of the three-dimensional shape of the organic target within the technique and attempts to comprehend the molecular basis of a disease, it has been confirmed to be more environmentally friendly than traditional drug discovery methods. In this overview, We will also talk about the fundamental steps involved in SBDD as well as the tools used in it. and focus on the fundamentals and applications of virtual screening (VS) in the context of SBDD and investigate novel approaches, starting from the system's early stages, which include pre-processing receptors and libraries, and continuing through docking, scoring, and publish-processing of top coring hits. Structure-based total layout is one of the earliest methods used in drug design. The most recent advancements in structure-based total virtual screening (SBVS) performance via ensemble docking, brought about suit, and consensus docking are also mentioned.

Published Paper   E-Certificate

"Structure based Drug Design ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 3, page no.259 - 268, March-2024, Available :https://ijsdr.org/papers/IJSDR2403040.pdf

Volume 9 Issue 3, March-2024

Pages : 259 - 268

Paper Reg. ID: IJSDR_210350

Published Paper Id: IJSDR2403040

Downloads: 000347097

Research Area: Pharmacy

Country: Sinnar , Maharashtra , India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2403040

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2403040

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition