COMPENDIOUS REVIEW ON ANIMAL MODELS AND SIGNALING PATHWAYS INVOLVED IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS

Selvakumar. S , Dr. P. Amudha , Esther Rani. E

Keywords: RA, Chemokines, GM-CSF, transgenic model, signaling pathways.

Rheumatoid arthritis is an autoimmune disease that can lead to joint discomfort, swelling, and stiffness. It occurs when the immune system malfunctions and targets the synovium, the tissue that lines the joints. As a part of the innate immune response, macrophages produce TNF, IL-6, IL-1, GM-CSF, IL-15, IL-18, IL-32, and chemokines that induce tissue inflammation. The inflammatory synovium thickens, causing the joint area to feel sensitive and painful, appear red and swollen, and become more difficult to move. Occasionally, RA can also result in complications for the heart, circulatory system, eyes, and/or lungs. Rheumatoid arthritis (RA) experimental models have made a significant contribution to our knowledge of the etiology and management of this inflammatory disease. Furthermore, a range of transgenic and genetically engineered knockout mice are available to analyze intricate disease processes. This is a big step forward for arthritis translational research. The current review will be focusing on improving knowledge of the experimental arthritis models in rodents and pathophysiology of RA based on the signaling pathways involved.

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"COMPENDIOUS REVIEW ON ANIMAL MODELS AND SIGNALING PATHWAYS INVOLVED IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 3, page no.225 - 231, March-2024, Available :https://ijsdr.org/papers/IJSDR2403036.pdf

Volume 9 Issue 3, March-2024

Pages : 225 - 231

Paper Reg. ID: IJSDR_210319

Published Paper Id: IJSDR2403036

Downloads: 000347075

Research Area: Pharmacy

Country: Chennai, Tamilnadu, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2403036

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2403036

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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