Concise review on pathophysiology and animal models of silicosis.

Esther Rani. E , Dr. Clement Atlee. W , Dr. P. Amudha , Udayakumari. S

Keywords: Silicosis, Pulmonary fibrosis, quartz, Pro-inflammatory cytokines, TGF-β1.

Silicosis is a type of pulmonary fibrosis, which is brought on by inhaling minute particles of silica, a common mineral present in quartz, sand, and many other kinds of rock. Workers exposed to silica dust in occupations like mining and construction are most susceptible to silicosis. Breathing difficulties may arise from lung scarring brought on by prolonged exposure to silica particles. Numerous animal models have already been created and used in research investigations to examine the pathophysiology and molecular underpinnings of the illness and to facilitate the search for therapeutics. There is an ongoing hunt for a better model because each experimental animal model that has been used thus far has pros and cons. Finding a better model will not only speed up basic research but also help with clinical issues and drug development. Rodent models are still a vital resource for researching human silicosis, despite certain anatomical and physiological variations. So, in this review, we can see a general insight into silicosis and various induction methods for modeling silicosis in rodents.

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"Concise review on pathophysiology and animal models of silicosis.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 3, page no.114 - 122, March-2024, Available :https://ijsdr.org/papers/IJSDR2403018.pdf

Volume 9 Issue 3, March-2024

Pages : 114 - 122

Paper Reg. ID: IJSDR_210235

Published Paper Id: IJSDR2403018

Downloads: 000347084

Research Area: Pharmacy

Country: Chennai, Tamilnadu, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2403018

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2403018

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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