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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Concise review on pathophysiology and animal models of silicosis. |
| Authors Name: | Esther Rani. E , Dr. Clement Atlee. W , Dr. P. Amudha , Udayakumari. S |
| Unique Id: | IJSDR2403018 |
| Published In: | Volume 9 Issue 3, March-2024 |
| Abstract: | Silicosis is a type of pulmonary fibrosis, which is brought on by inhaling minute particles of silica, a common mineral present in quartz, sand, and many other kinds of rock. Workers exposed to silica dust in occupations like mining and construction are most susceptible to silicosis. Breathing difficulties may arise from lung scarring brought on by prolonged exposure to silica particles. Numerous animal models have already been created and used in research investigations to examine the pathophysiology and molecular underpinnings of the illness and to facilitate the search for therapeutics. There is an ongoing hunt for a better model because each experimental animal model that has been used thus far has pros and cons. Finding a better model will not only speed up basic research but also help with clinical issues and drug development. Rodent models are still a vital resource for researching human silicosis, despite certain anatomical and physiological variations. So, in this review, we can see a general insight into silicosis and various induction methods for modeling silicosis in rodents. |
| Keywords: | Keywords: Silicosis, Pulmonary fibrosis, quartz, Pro-inflammatory cytokines, TGF-β1. |
| Cite Article: | "Concise review on pathophysiology and animal models of silicosis.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 3, page no.114 - 122, March-2024, Available :http://www.ijsdr.org/papers/IJSDR2403018.pdf |
| Downloads: | 000337362 |
| Publication Details: | Published Paper ID: IJSDR2403018 Registration ID:210235 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: 114 - 122 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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