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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | PROCESS VALIDATION OF DOMPERIDONE SUSTAINED RELEASE AND PANTOPRAZOLE ENTERIC COATED TABLET IN TABLET FORMULATION |
| Authors Name: | Sunita Raina , Gulbahar , Saurabh Pant |
| Unique Id: | IJSDR2307149 |
| Published In: | Volume 8 Issue 7, July-2023 |
| Abstract: | A proton pump inhibitor that is a member of the benzimidazole family, pantoprazole was manufactured using the direct compression method, microcrystalline cellulose as filler, mannitol and dicalcium phosphate as diluents, croscarmellose sodium as a disintegrating agent, magnesium stearate as a glidant, and talc as a lubricant. Since it involves fewer unit operations than wet granulation, direct compression is more cost-effective. As a result, the cost of producing tablets will be lower since there will be less equipment, less power usage, less space, less time, and less labour. The manufactured tablets were tested for uniformity of drug content, weight variation, friability, and hardness, and it was discovered that the results meet official standards. The produced tablets were coated using a dip coating technique and an enteric coating polymer, such as cellulose acetate phthalate. Using an acidic buffer pH of 1.2 and a phosphate buffer pH of 6.8, the in vitro release was investigated. The best batches were those that had been prepared, with the hardness, drug content, time till disintegration, and cumulative drug release % starting after 120 minutes and reaching 99.72 after 180 minutes. Studies on stability showed that the created tablets maintained their medicinal qualities for three months at room temperature and at 40°C and 75 percent relative humidity |
| Keywords: | Direct compression, Pantoprazole, Proton pump inhibitor |
| Cite Article: | "PROCESS VALIDATION OF DOMPERIDONE SUSTAINED RELEASE AND PANTOPRAZOLE ENTERIC COATED TABLET IN TABLET FORMULATION", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 7, page no.993 - 1001, July-2023, Available :http://www.ijsdr.org/papers/IJSDR2307149.pdf |
| Downloads: | 000338536 |
| Publication Details: | Published Paper ID: IJSDR2307149 Registration ID:207904 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: 993 - 1001 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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