|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Molecular docking studies, drug-likeness and in-silico ADMET and adverse effect prediction of some novel Spirooxindole derivatives for Alzheimer`s disease |
| Authors Name: | Tanjima Tarique Laskar , Monica Arora |
| Unique Id: | IJSDR2307029 |
| Published In: | Volume 8 Issue 7, July-2023 |
| Abstract: | Spirooxindole is a versatile scaffold which has been extensively studied in pharmaceutical and synthetic chemistry. In the medicinal field, a number of compounds featuring spirooxindole motif have displayed excellent pharmacological activities. Spirooxindole derivatives have a highly precious synthetic framework due to their diversified biological properties and it is found to play a key role in the treatment of Alzheimer’s disease by preventing amyloid fibril formation at early stages of this disease. Recent progress and development in the bioactivity profiles of spirooxindole derivatives have demonstrated their notable position in present-day drug discovery studies. In this study, five spirooxindole derivatives were designed and in-silico studies such as drug likeliness, molecular docking and ADMET studies were performed. All the designed derivatives were found to exhibit docking scores higher than the standard drug Donepezil and toxicity studies has also revealed that the designed compounds didn’t exhibit any toxicity and are considered to be safe. Among the designed derivatives, compound A1 showed highest binding affinity in docking study and it has also showed Blood Brain Barrier (BBB) permeability in ADME studies which is essential for treatment of early stages of Alzheimer disease. Furthermore, it can be considered that the multidirectional development of novel drugs containing this spirooxindole scaffold will continue to be the research hotspot in the field of medicinal chemistry in future. |
| Keywords: | Alzheimer’s disease, Molecular Docking, drug-likeliness, ADME, Toxicity studies |
| Cite Article: | "Molecular docking studies, drug-likeness and in-silico ADMET and adverse effect prediction of some novel Spirooxindole derivatives for Alzheimer`s disease", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 7, page no.212 - 227, July-2023, Available :http://www.ijsdr.org/papers/IJSDR2307029.pdf |
| Downloads: | 000338536 |
| Publication Details: | Published Paper ID: IJSDR2307029 Registration ID:207620 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: 212 - 227 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn