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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Insilico design of dibenzazepine derivatives as GABA -A agonist |
| Authors Name: | Rachel Mathew , Anjana V S , Fathima A S , Amina A , Alfiya N |
| Unique Id: | IJSDR2307021 |
| Published In: | Volume 8 Issue 7, July-2023 |
| Abstract: | Convulsion is considered as the most common serious brain conditions. Surgery is the only way in the eradication of convulsion. This project aims at designing dibenzazepine derivatives as anticonvulsant agents by agonistic activity in GABA-A receptor. Different dibenzazepine derivatives were designed using ACD Lab Chemsketch12.0 software and their properties were predicted using Molinspiration software. The designed derivatives showing optimal physicochemical properties were selected for docking studies. The various methodology used in the study include random selection of drugs, ChemSketch for drawing 2D structure, docking using AutoDock program and visualising the output using PyMOL. The ligands which shows good binding score with GABA-A receptor were selected as anticonvulsant drugs and carbamazepine was selected as standard drug. |
| Keywords: | Convulsion, Insilico, Chemsketch, Docking, PyMOL, Carbamazepine, GABA-A |
| Cite Article: | "Insilico design of dibenzazepine derivatives as GABA -A agonist", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 7, page no.146 - 154, July-2023, Available :http://www.ijsdr.org/papers/IJSDR2307021.pdf |
| Downloads: | 000338536 |
| Publication Details: | Published Paper ID: IJSDR2307021 Registration ID:207579 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: 146 - 154 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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