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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and Evaluaton of Cyclodextrin based Clotrimazole Nanogel |
| Authors Name: | Dr. Mithun M. Bandivadekar , Ms. Aditi S. Jadhav |
| Unique Id: | IJSDR2307017 |
| Published In: | Volume 8 Issue 7, July-2023 |
| Abstract: | The objective of this study was to improve the solubility and dissolution profile of clotrimazole in the vaginal fluid for the treatment of fungal infection, a gamma-cyclodextrin-based clotrimazole nanogel was created for vaginal administration.The emulsion solvent evaporation process was used to prepare gamma-cyclodextrin-based nanogel. Aqueous phase was prepared using γCD, NaOH, EGDE and HPMC (1 %,2% w/w). Organic phase was prepared using Span 80(0, 0.5, 1, 2% w/v) in organic solvent dichloromethane. Aqueous phase was added to organic phase and homogenization was done followed by lyophilization. Formed solution was treated in an ultrasonic bath. The water was evaporated using a rotavapour.Schrodinger molecular docking software revealed a glide score of - 2.85 kcal/mol for the gamma-cyclodextrin-clotrimazole complex, indicating the establishment of a hydrogen bond with a length of 2.4. The AL type of curve with a stability constant of 545 M-1.was visible in the phase solubility diagram, indicating the production of 1:1 complexes. F8 was chosen as the optimal formulation batch. The mucoadhesion force (g) for batch F8 was 13.53g. When compared to pure Clotrimazole in the simulated vaginal fluid, the solubility of Clotrimazole in loaded nanogel increased by 15.45 fold. At the conclusion of six hours, there had been a 79.67% drug release with a drug flux of 1.3596 g/cm2/h. The Korsmeyer-Peppas model was used in the formulation of nanogel, with a r2 value of 0.9984. The final formulation showed the highest zone of inhibition which is of standard zone of inhibition. |
| Keywords: | Clotrimazole, Gamma-cyclodextrin, EGDE, Nanogel |
| Cite Article: | "Formulation and Evaluaton of Cyclodextrin based Clotrimazole Nanogel", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 7, page no.121 - 133, July-2023, Available :http://www.ijsdr.org/papers/IJSDR2307017.pdf |
| Downloads: | 000338537 |
| Publication Details: | Published Paper ID: IJSDR2307017 Registration ID:207396 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: 121 - 133 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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