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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and Evaluation of sustained release floating microbeads of ketoprofen |
| Authors Name: | Rajan Sah , Keerthi H. S. , Shivanand K. Mutta , Sowmya T. P. , Pradeep Kumar Patel |
| Unique Id: | IJSDR2307014 |
| Published In: | Volume 8 Issue 7, July-2023 |
| Abstract: | Aim:The main intention of the present study is to develop the ideal floating microbeads of Ketoprofenfor prolongation of the gastric retention time in stomach and enhance the patient compliance in the treatment of pain. Objective:Ketoprofen is apropionic acid derivative, it reversibly inhibits cyclooxygenase-1 and 2 (COX-1&2) enzymes, resulting to decrease formation of prostaglandin precursors. The elimination half-life of Ketoprofen is 2.4hrs. In the latest research work the floating drug delivery system of Ketoprofen floating microbeads were prepared by using some polymers are sodium alginate, HPMC K100M, Carbopol 934, Methyl cellulose as a polymer and calcium carbonate used as gas forming agent. Method:The floating microbeads were prepared by ionotropic gelation technique. By the FTIR technique the compatibility of drug and polymers were compared. The prepared microbeads were evaluated for physical characterization floating lag time, swelling index, entrapment efficiency, buoyancy studies, invitro drug |
| Keywords: | Key Words:- Ketoprofen, Rheumatoid arthritis, ionotropic gelation, floating microbeads, Gastric residence time, Buoyancy. |
| Cite Article: | "Formulation and Evaluation of sustained release floating microbeads of ketoprofen ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 7, page no.89 - 100, July-2023, Available :http://www.ijsdr.org/papers/IJSDR2307014.pdf |
| Downloads: | 000338537 |
| Publication Details: | Published Paper ID: IJSDR2307014 Registration ID:207561 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: 89 - 100 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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