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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Development and Validation of a Spectrofluorimetric Method for the Estimation of Baicalein in Bulk and Formulation |
| Authors Name: | Dr. Sachin Shivling Bhusari , Aarti Raju Popalghat , Dr.Pravin.S. Wakte |
| Unique Id: | IJSDR2306261 |
| Published In: | Volume 8 Issue 6, June-2023 |
| Abstract: | A simple, accurate, precise, sensitive and cost-effective spectrofluorimetric method was developed and validated for the estimation of baicalein in bulk and formulation. The relative fluorescence intensity of baicalein was measured in pure methanol at an excitation wavelength of 371 nm and an emission wavelength 433 nm. Proposed method was found to be linear over the range of 50 to 800 ng/ml with correlation coefficient 0.999. Proposed method was validated using different analytical method validation parameters viz. Accuracy, precision, LOD, LOQ, robustness and ruggedness using QC standards as per the ICH guidelines. The percentage recovery was found to be 101.43% and percentage RSD values were found to be less than 2 for accuracy and precision studies. The detection and quantification limits for the proposed method were found to be 2.14ng/ml and 6.48ng/ml, respectively. A simple, accurate, precise, sensitive yet cost-effective spectrofluorimetric method was developed for the estimation of baicalein in bulk and formulation. The said spectrofluorimetric method was found to be economic as it comprises with methanol: water (40:60) as a solvent. |
| Keywords: | Spectrofluorimetry, Baicalein, Validation,Excitation, Emission |
| Cite Article: | "Development and Validation of a Spectrofluorimetric Method for the Estimation of Baicalein in Bulk and Formulation", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 6, page no.1910 - 1915, June-2023, Available :http://www.ijsdr.org/papers/IJSDR2306261.pdf |
| Downloads: | 000346988 |
| Publication Details: | Published Paper ID: IJSDR2306261 Registration ID:207537 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: 1910 - 1915 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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