INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Don`t underestimate the power of a common drug!! - An interesting case of Baclofen encephalopathy in a patient with acute on chronic renal impairment
Authors Name:
Dr. Ajay Dalal
, Dr. Abhinav , Dr. Vasundhara Aggarwal , Dr. Divyani Garg , Dr.(Lt. General) Ashok Kumar Hooda
Unique Id:
IJSDR2306036
Published In:
Volume 8 Issue 6, June-2023
Abstract:
People with deranged renal functions are prone for baclofen encephalopathy. Baclofen is a centrally acting GABA receptor agonist and helps in reducing the muscle spasticity in upper motor neuron lesions like traumatic brain injury, spinal cord injuries, central demyelination and other off label indications like intractable hiccups, alcoholic liver disease, and trigeminal neuralgia. The most common neurological side effects of the drug include sedation, confusion, neuropsychiatric manifestations, tremors, insomnia, seizures etc. Baclofen has a renal mode of excretion and therefore, the side effects of the drug in usual therapeutic doses can get manifested in exaggerated manner early in patients with suboptimal renal functions. We present an interesting case of baclofen encephalopathy in our patient with renal dysfunction to highlight early recognition and rapid management of this drug toxicity. He improved remarkably after two sessions of haemodialysis.
Keywords:
Baclofen, drug toxicity, renal impairment, hemodialysis
Cite Article:
"Don`t underestimate the power of a common drug!! - An interesting case of Baclofen encephalopathy in a patient with acute on chronic renal impairment", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 6, page no.241 - 244, June-2023, Available :http://www.ijsdr.org/papers/IJSDR2306036.pdf
Downloads:
000337352
Publication Details:
Published Paper ID: IJSDR2306036
Registration ID:207056
Published In: Volume 8 Issue 6, June-2023
DOI (Digital Object Identifier):
Page No: 241 - 244
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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