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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Issue: May 2023

Volume 8 | Issue 5

Impact factor: 8.15

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Paper Title: A Review on Formulation and Evaluation of microspheres of cyclobenzaprine HCl- Skeleton muscle relaxant
Authors Name: Saurav Sharma
Unique Id: IJSDR2305007
Published In: Volume 8 Issue 5, May-2023
Abstract: The microsphere has free-flowing powder properties and contains proteins as well as synthetic or natural polymers. This polymer seems to be biodegradable in nature and particles having below 200 µm. Cyclobenzaprine hydrochloride is a sympathomimetic muscle relaxant that has been widely used for the relief of muscle spasms associated with acute, painful musculoskeletal conditions for the past 30 years. It activates the locus cerelus in the brain stem leading to an increased release of nor epinephrine in the ventral horn of the spinal cord & subsequent inhibitory action of nor epinephrine on alpha motor neurons. Cyclobenzaprine related to the first-generation Tricyclic antidepressants. Such Tricyclics including amitriptyline act to inhibit the uptake of nor epinephrine, resulting in increased trans synaptic or epinephrine concentration. They have been shown to exert analgesic effect in chronic nerve & muscle pain. The current goal of this review is to investigate multiple elements of the microparticulate drug-delivery system, such as formulation methods, evaluation, and characterization.
Keywords: Microspheres, Cyclobenzaprine hydrochloride, polymer, solvent evaporation, muscle relaxants, evaluation
Cite Article: "A Review on Formulation and Evaluation of microspheres of cyclobenzaprine HCl- Skeleton muscle relaxant", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.51 - 56, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305007.pdf
Downloads: 000222060
Publication Details: Published Paper ID: IJSDR2305007
Registration ID:205974
Published In: Volume 8 Issue 5, May-2023
DOI (Digital Object Identifier):
Page No: 51 - 56
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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