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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | IN-VITRO EVALUATION OF EXTRACT OF FABIANA IMBRICATA |
| Authors Name: | K.Nagakumari , Dr.K.Ravikumar , Mrs.sowjnaya |
| Unique Id: | IJSDR2304138 |
| Published In: | Volume 8 Issue 4, April-2023 |
| Abstract: | ABSTRACT The study investigated the anti-inflammatory activity of the ethanolic extract of Fabiana imbricate (bad mustard). I have been observed of whole plant of Fabiana imbricate has anti-inflammatory activity. The anti-inflammatory activity of the ethanolic extract of Fabiana imbricate (bad mustard) leaf,stem,root was evaluated using four in vitro- based assays heat induced hemolysis inhibition, Inhibition of albumin denaturation, Anti- proteinase action, preparation of red blood cells (RBCS) suspension. Diclofenac sodium was used as standard, control used as a water. The whole plant was taken too comparable to each other. Results showed that the anti-inflammation activity, the ability of Fabiana imbricate leaf, stem, root extract to inhibit the membrane stabilization in leaf (60µg/ml in 0.17), to inhibit the membrane stabilization in in stem (20µg/ml in 0.4), and to inhibit the membrane stabilization in root (20µg/ml in 0.34), was studied. It was effective in inhibiting the membrane stabilization in leaf (60µg/ml in 0.17), compare to stem and root and control, standard diclofenac sodium (200µg/ml in 0.053). In the present study, results indicate that the ethanolic extracts of Fabiana imbricate possess anti-inflammatory properties. These activities may be due to the strong occurrence of polyphenolic compounds such as alkaloids, flavonoids, tannins, steroids, and phenyl, The extract fractions serve as free-radical inhibitors or scavenger or acting possibly as primary oxidants and inhibited the heat induced albumin denaturation, proteinase activity, and stabilized the Red Blood Cells membrane. In the present study, results indicate that the ethanolic extracts of Fabiana imbricate possess anti-inflammatory properties. These activities may be due to the strong occurrence of polyphenolic compounds such as alkaloids, flavonoids, tannins, steroids, and phenyl, The extract fractions serve as free-radical inhibitors or scavenger or acting possibly as primary oxidants and inhibited the heat induced albumin denaturation, proteinase activity, and stabilized the Red Blood Cells membrane. |
| Keywords: | Keywords: Fabiana imbricate (bad mustard), Anti-inflammatory activity, Ethanolic extracts, and four in vitro-based assays heat induced hemolysis inhibition, Inhibition of albumin denaturation, Anti-proteinase action, preparation of red blood cells (RBCS) suspension. |
| Cite Article: | " IN-VITRO EVALUATION OF EXTRACT OF FABIANA IMBRICATA", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 4, page no.789 - 794, April-2023, Available :http://www.ijsdr.org/papers/IJSDR2304138.pdf |
| Downloads: | 000337348 |
| Publication Details: | Published Paper ID: IJSDR2304138 Registration ID:205140 Published In: Volume 8 Issue 4, April-2023 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.35104 Page No: 789 - 794 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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