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Issue: March 2023

Volume 8 | Issue 3

Impact factor: 8.15

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Paper Title: Association between renal dysfunction markers and Creatine Kinase levels in Hypothyroidism.
Authors Name: Tejomani M
Unique Id: IJSDR2303038
Published In: Volume 8 Issue 3, March-2023
Abstract: Hypothyroidism is one of the most common endocrine disorders in clinical practice. It can affect the kidney function through various mechanisms, such as decreased cardiac output, increased vascular resistance, intrarenal vasoconstriction, reduced production and activity of hormones that regulate blood pressure and fluid balance, and altered kidney structure and feedback. Hypothyroidism can reduce renal plasma flow, glomerular filtration rate, and glomerular transcapillary pressure, which are important for kidney function. Hypothyroid myopathy is a common clinical feature in patients with hypothyroidism. The study was taken up to determine the influence of thyroid hormone on renal dysfunction markers, serum creatinine and cystatin C and on myopathy marker total creatine kinase levels and to evaluate the association between these dysfunction markers in hypothyroid cases. Serum T3, T4, TSH, Total Creatine Kinase, Cystatin C and Creatinine levels were estimated. Creatinine Clearance was calculated by using the Cockcroft-Gault formula and eGFR by using the MDRD formula. The elevation of serum creatinine in the study may be attributed to an increase in total creatine kinase levels which may be due to hypothyroid myopathy or decreased clearance by the kidneys. In contrast to creatinine concentrations, Cystatin C levels are lower in the hypothyroid cases suggesting a paradoxical relationship between them, though both are renal dysfunction markers. Hence interpretation of Cystatin C must be cautiously done in hypothyroidism.
Keywords: Keywords: Creatinine, creatinine clearance, cystatin C, eGFR, hypothyroidism, renal dysfunction, myopathy, thyroid hormone, total creatine kinase.
Cite Article: "Association between renal dysfunction markers and Creatine Kinase levels in Hypothyroidism.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 3, page no.242 - 247, March-2023, Available :http://www.ijsdr.org/papers/IJSDR2303038.pdf
Downloads: 00021
Publication Details: Published Paper ID: IJSDR2303038
Registration ID:204174
Published In: Volume 8 Issue 3, March-2023
DOI (Digital Object Identifier):
Page No: 242 - 247
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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