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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Early detection of ovarian cancer through urinary CA 125. |
| Authors Name: | DR.PANKHUDI GUPTA , DR.SRISHTI SONI , DR.SAJAG KUMAR GUPTA |
| Unique Id: | IJSDR2301177 |
| Published In: | Volume 8 Issue 1, January-2023 |
| Abstract: | TITLE: Early detection of ovarian cancer through urinary CA 125. INTRODUCTION: Ovarian cancer is the most lethal among all gynecologic cancers, causing more deaths than any other cancer of the female reproductive system (Alzheimer’s Association,2009). It is the fifth leading cause of cancer deaths in females and account approximately 50% of all death from gynaecologic cancers. We proposed detection of urinary Ca-125 in a case of ovarian mass for early detection of ovarian cancer. Urine CA-125 and serum CA-125 were measured by commercially available standard ELISA kits method using kit for CA-125 levels(Calbiotech). Histopathology :Adnexal masses were excised and tissue obtained was fixed in 10% buffered formalin, embedded in paraffin. Sections were cut and stained with H & E for routine histopathological diagnosis and the grading in the cases of malignant lesion was done. We found that maximum serum as well as urinary CA-125 value was in a case of papillary serous adenocarcinoma (histologically High grade) with serum CA-125 957 U/ml and urinary CA 125 207.54 U/ml whereas the lowest levels were recorded in a case of mucinous cystadenoma with serum CA-125 9.5 U/ml and Urinary CA-125 2.36 U/ml. We also found that there was a significant and definite correlation in serum and urinary CA-125 values. The serum CA-125 values were lower in the cases of benign tumors and higher in the cases of malignant tumors, similarly the urinary CA-125 values were lower in benign cases and higher in malignant cases. |
| Keywords: | ca125,papillary carcinoma ovary, serum ca125 |
| Cite Article: | "Early detection of ovarian cancer through urinary CA 125.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 1, page no.1114 - 1117, January-2023, Available :http://www.ijsdr.org/papers/IJSDR2301177.pdf |
| Downloads: | 000337212 |
| Publication Details: | Published Paper ID: IJSDR2301177 Registration ID:203717 Published In: Volume 8 Issue 1, January-2023 DOI (Digital Object Identifier): Page No: 1114 - 1117 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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