SYNERGISTIC HEPATOPROTECTIVE ACTIVITY OF CHRYSIN AND CURCUMIN AGAINST LIVER FIBROSIS
Meena Bandiya
, Dr. Dharmesh Sisodiya , Dr. Kamlesh Dhashora , Pushpendra Ahirwar
curcumin, chrysene, hepatotoxicity, liver fibrosis, natural product
Curcumin and chrysin Oxidative stress has been considered a key causing factor of liver damage induced by a variety of agents, including alcohol, drugs, viral infections, environmental pollutants, and dietary components, which in turn results in the progression of liver injury, non-alcoholic steatohepatitis, non-alcoholic liver disease, liver fibrosis, and cirrhosis. Curcumin is one of the most commonly used indigenous molecules endowed with various shielding functionalities that protect the liver. The aim of the present study is to curcumin and chrysene against synergistic pharmacological effects and molecular mechanisms, as well as clinical evidence, of curcumin as a lead compound in the prevention and treatment of oxidative associated liver diseases. “hepatoprotective or hepatotoxicity or liver” along with “oxidative or oxidant.” Results showed that curcumin exerts remarkable protective and therapeutic effects on oxidative-associated liver diseases through various cellular and molecular mechanisms. Those mechanisms include suppressing the proinflammatory cytokines, lipid peroxidation products, PI3K/Akt, and hepatic stellate cells activation, as well as ameliorating cellular responses to oxidative stress such as the expression of Nrf2, SOD, CAT, GSH, GPx, and GR. Taking together, curcumin itself acts as a free radical scavenger over the activity of different kinds of ROS via its phenolic, β-diketone, and methoxy group. Further clinical studies are still needed to recognize curcumin's structure-activity relationships and molecular mechanisms in oxidative-associated liver diseases.
"SYNERGISTIC HEPATOPROTECTIVE ACTIVITY OF CHRYSIN AND CURCUMIN AGAINST LIVER FIBROSIS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 1, page no.882 - 891, January-2023, Available :https://ijsdr.org/papers/IJSDR2301141.pdf
Volume 8
Issue 1,
January-2023
Pages : 882 - 891
Paper Reg. ID: IJSDR_203670
Published Paper Id: IJSDR2301141
Downloads: 000347214
Research Area: Medical Science
Country: ujjain, Madhya Pradesh, india
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
