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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | DRUG REPURPOSING |
| Authors Name: | Janhavi Ashokrao Gedam , Kalyani Suresh Khiradkar , Sakshi Sakharam More , Pooja Shankarrao Ingole |
| Unique Id: | IJSDR2212085 |
| Published In: | Volume 7 Issue 12, December-2022 |
| Abstract: | Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of ‘old’ drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compounds, with potentially lower overall development costs and shorter development timelines. Various data-driven and experimental approaches have been suggested for the identification of repurposable drug candidates; however, there are also major technological and regulatory challenges that need to be addressed. Drug repositioning utilizes the combined efforts of activity-based or experimental and in silico-based or computational approaches to develop/identify the new uses of drug molecules on a rational basis. It is, therefore, believed to be an emerging strategy where existing medicines, having already been tested safe in humans, are redirected based on a valid target molecule to combat particularly, rare, difficult-to-treat diseases and neglected diseases. In this Review, we present approaches used for drug repurposing (also known as drug repositioning), discuss the challenges faced by the repurposing community and recommend innovative ways by which these challenges could be addressed to help realize the full potential of drug repurposing. |
| Keywords: | Approaches, repurposed drugs, challenges, expensive, time consuming |
| Cite Article: | "DRUG REPURPOSING", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 12, page no.550 - 555, December-2022, Available :http://www.ijsdr.org/papers/IJSDR2212085.pdf |
| Downloads: | 000337214 |
| Publication Details: | Published Paper ID: IJSDR2212085 Registration ID:203022 Published In: Volume 7 Issue 12, December-2022 DOI (Digital Object Identifier): Page No: 550 - 555 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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