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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | RP-HPLC Method Development and Validation for Simultaneous Estimation of Cetirizine Hydrochloride and Griseofulvin Pharmaceutical Dosage Form. |
| Authors Name: | Harshvardhan Tanaji suryawanshi , Ashpak M Tamboli , Hasan I Shaikhmulani , Rohan T Kshirsagar , Dipak R phalle |
| Unique Id: | IJSDR2210024 |
| Published In: | Volume 7 Issue 10, October-2022 |
| Abstract: | A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of Cetirizine Hydrochloride and Griseofulvin in bulk and tablet dosage form. C18 C-18Agilent Zorbax Bonus –RP (250 x 4.6 mm, Particle size -5 Micron) was used in this method. The mobile phase comprises of : Acetonitrile : 0.1 % Trifluoroaceticacid (50:50, % v/v) with flow rate 1 mL/min (Photodiode array Detector). The retention time for Cetirizine Hydrochloride was 5.16 min and for Griseofulvin was 5.00 min. The detection concentration was linear over 4-6 µg/mL for Cetirizine Hydrochloride and 200-300 µg/mL for Griseofulvin . The regression equation of Cetirizine Hydrochloride and Griseofulvin were found to be y = 75272x – 6702 and y = 68965x - 17908 respectively with regression co-efficient of Cetirizine Hydrochloride and Griseofulvin were 1 and 0.999. so, the present work is aimed for Development of simple, reproducible chromatographic RP-HPLC method for simultaneous estimation of Cetirizine Hydrochloride and Griseofulvin. The developed method was successfully validated in accordance to ICH guideline. Hence the method can be conveniently adopted for the routine analysis in quality control laboratories. |
| Keywords: | Cetirizine Hydrochloride, Griseofulvin, RP-HPLC, Method Development, Validation. |
| Cite Article: | "RP-HPLC Method Development and Validation for Simultaneous Estimation of Cetirizine Hydrochloride and Griseofulvin Pharmaceutical Dosage Form.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 10, page no.131 - 141, October-2022, Available :http://www.ijsdr.org/papers/IJSDR2210024.pdf |
| Downloads: | 000337215 |
| Publication Details: | Published Paper ID: IJSDR2210024 Registration ID:201945 Published In: Volume 7 Issue 10, October-2022 DOI (Digital Object Identifier): Page No: 131 - 141 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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