PREPARATION OF NANOPARTICLES OF OXCARBAZEPINE BY HIGH PRESSURE HOMOGENIZATION TECHNIQUE
Dr Amol Yadavrao Ghodke
, Habiba Hanif Mulla
Oxcarbazepine, Nanoparticles, Polymers, Himogenization, Lyophilization, Nanosuspension.
A majority of drugs developed and used today suffer from poor bioavailability due to poor aqueous solubility or low dissolution rate. One of the main focus of pharmaceutical technology is developing novel strategies to enhance the solubility of poorly water soluble drugs. Nano suspensions are a promising strategy for improving the dissolution rate and oral bioavailability of poorly water soluble drugs by reducing the particle size or transforming drugs from crystalline to an amorphous state. In the present time an increasing attention has focused on nano suspensions considering these general advantage of nanotechnology ,the main objective of the present investigation was to prepare Nanosuspension of Oxcarbazepine which is widely used as antiepileptic drug belongs to BCS class II (low solubility, high permeability). Nanosuspension of Oxcarbazepine we are produced by combining nano precipitation and high pressure homogenization technique with using polymer like poloxamer 188,soluplus ,PLGA etc. All the suspension prepared with the different drug : polymer ratio showed a significant decrease in particle size with increase in the number of homogenization cycles and pressure. Nanosuspension were prepared and analyzed for particle size, zeta potential ,entrapment efficacy and in vitro drug release study. Batch (PLG2) drug : polymer:stabilizer (1:0.5:0.5) ,shows particle size (229.1nm) ,P.I.(0.411 ) , zeta potential (-0.2 ), % entrapment efficacy ( 73.86 ) and better drug release. Oxcarbazepine nanoparticles were produced by converting nanosuspension into dry powder by lyophilization technique. The physicochemical properties of drug and its nanoparticles were characterized by SEM,XRD,FT -IR,DSC, in - vitro drug dissolution and saturation solubility.The DSC and XRD results indicated that nano precipitation led to amorphization of oxcarbazepine. An increase in the stability of nanoparticles was also assured by sufficient adsorption of the polymer on to the surface.
"PREPARATION OF NANOPARTICLES OF OXCARBAZEPINE BY HIGH PRESSURE HOMOGENIZATION TECHNIQUE", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 9, page no.195 - 222, September-2022, Available :https://ijsdr.org/papers/IJSDR2209034.pdf
Volume 7
Issue 9,
September-2022
Pages : 195 - 222
Paper Reg. ID: IJSDR_201488
Published Paper Id: IJSDR2209034
Downloads: 000347217
Research Area: Pharmacy
Country: Nilanga, Dist Latur, Maharastra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
