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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | STUDY OF HOMOEOPATHIC MEDICINE CURCUMA LONGA AND ITS BIOSYNTHESISED SILVER NANOPARTICLES - ANTI FUNGAL AND ANTI MELANIN ACTIVITY - A NANO-COSMETOLOGICAL PERSPECTIVE |
| Authors Name: | SANA KT , ARCHANA C INGOLE , SHANKAR SHETTY |
| Unique Id: | IJSDR2208115 |
| Published In: | Volume 7 Issue 8, August-2022 |
| Abstract: | ABSTRACT. Background-. Nanoscale science (or nanoscience) studies the phenomena, properties and responses of materials at atomic, molecular and macromolecular scales, and in general at sizes between 1-100 nm. Recent studies reveal that homeopathic remedies contain nanoparticles (NP’s) of source materials formed by potentization. Skin is an important component of body image and has immense physiological importance for both women and men. Skin pigmentation can be a source of significant emotional distress in individuals. Along human history, people have been struggling with numerous skin diseases, especially skin pigmentation (hyper/hypo-pigmentation). It is well documented that tyrosinase is an essential enzyme, which contributes towards pigment formation in mammalian's body as well as in plants, microorganisms and fungi. The rate-limiting step in melanogenesis is the conversion of L-DOPA to melanin, through the action of tyrosinase enzyme. Area of interest of this study focus on this step of melanogenesis. Objectives- Homoeopathic mother tincture(Q) and potencies(dilutions) 6CH ,12CH ,30CH, 200CH &1M of Curcuma longa (CL) (Purchased from Willmar Schwabe India Pvt.Ltd) was used for this entire study. In this study our aim was to investigate the anti-fungal and anti-melanin activity (mushroom tyrosinase inhibitory activity) of Curcuma longa Q, potencies and their corresponding silver nanoparticle (SNP’s) preparations and its application in a Cosmetological perspective. Methods-SNP’s were synthesised from Q, potencies and characterisation was done using UV-spectroscopy and Scanning Electron Microscopy (SEM). Its anti-fungal activity and anti-melanin activity (mushroom tyrosinase inhibitory activity) was studied in detail using Agar well diffusion method and Mushroom tyrosinase inhibitory assay by using L-DOPA respectively. Results - Characterizations of nanoparticles were done using different methods, which included ultraviolet-visible spectroscopy, where the silver nanoparticles showed an absorption peak at around 350nm for Q,250nm for 6CH, 248nm for 12CH and 30CH,250nm for 200CH and 249nm for 1M.SEM shows that shape of the particles are spherical and size was up to 100nm.The antifungal activity for Aspergillus niger shows highest zone of inhibition of 10mm for Q and 1M. And for White rot fungi highest zone of inhibition of 10mm was obtained for CL 1M SYN.The mushroom tyrosinase inhibitory assay shows highest inhibition rate of 87.92±.041% for CL 30C (IC50 83.33mg) and lowest inhibitory activity of 56.67±.046% for CL 200C (IC50 138.8±24mg). The medicinal and SNP synthesised samples of CL was showing a very potent mushroom tyrosinase inhibitory activity. Conclusions-Through this study it was evident that homoeopathic medicines and the synthesised SNP’S were found to be effective as an anti-fungal agent against Aspergillus niger and White rot fungi which are causative of many fungal infections. As well as it was found to be a potent tyrosinase inhibitor in mushroom tyrosinase assay. Hence, it can be used as an anti-melanin agent in treating various skin pigmentations and Cosmetological aspects. |
| Keywords: | KEYWORDS: Nanoparticles, Silver nanoparticles, Homoeopathic medicine, Potentization, Curcuma longa, Antifungal activity, Anti melanin activity, Mushroom tyrosinase inhibition assay |
| Cite Article: | "STUDY OF HOMOEOPATHIC MEDICINE CURCUMA LONGA AND ITS BIOSYNTHESISED SILVER NANOPARTICLES - ANTI FUNGAL AND ANTI MELANIN ACTIVITY - A NANO-COSMETOLOGICAL PERSPECTIVE", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 8, page no.773 - 781, August-2022, Available :http://www.ijsdr.org/papers/IJSDR2208115.pdf |
| Downloads: | 000337348 |
| Publication Details: | Published Paper ID: IJSDR2208115 Registration ID:201382 Published In: Volume 7 Issue 8, August-2022 DOI (Digital Object Identifier): Page No: 773 - 781 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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