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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Hepatoprotective Activity of Carvacrol in Paracetamol Induced Hepatotoxicity |
| Authors Name: | Umesh Kumar Singh Sikarwar , Manoj Singh Bhadouria , Navesh Veer |
| Unique Id: | IJSDR2208058 |
| Published In: | Volume 7 Issue 8, August-2022 |
| Abstract: | ABSTRACT- AIM-The main aim of the present work is to study the hepatoprotective role of Carvacrol in Paracetamol induced hepatotoxicity. MATERIAL & METHODS-Carvacrol was evaluated for their possible hepatoprotective activity by paracetamol induced hepatic damage. Standard drug Silymarin was used as reference compound. For the paracetamol induced hepatotoxicity studies, paracetamol (500mg/kg po) suspension was prepared using 1% gum acacia and was administered to all animals except the animals of the normal control group. Silymarin (100 mg/kg po) was used as standard. The biochemical parameters like SGOT, SGPT, ALP and bilirubin were estimated using respective assay kits according to the methods described. RESULTS- Effect of carvacrol and paracetamol on SGPT level of rats is shown in table. A single dose of paracetamol (500 mg/kg) caused significant elevation in the serum SGPT level when compared to normal group, while on treatment with carvacrol, a significant dose dependent reduction was observed. Paracetamol (500 mg/kg) caused significant elevation in the serum SGOT level when compared to normal group, while on treatment with carvacrol, a significant dose dependent reduction was observed. A single dose of paracetamol (500 mg/kg) caused significant elevation in the serum ALP level when compared to normal group, while on treatment with carvacrol, a significant dose dependent reduction was observed. CONCLUSION- The selected carvacrol are widely employed in various liver disorders in traditional systems of medicine. The present pharmacological evaluation will provide scientific data about the rationale behind their use. |
| Keywords: | Hepatoprotective Activity, Carvacrol, Paracetamol, SGOT, SGPT, ALP |
| Cite Article: | "Hepatoprotective Activity of Carvacrol in Paracetamol Induced Hepatotoxicity", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 8, page no.433 - 438, August-2022, Available :http://www.ijsdr.org/papers/IJSDR2208058.pdf |
| Downloads: | 000337214 |
| Publication Details: | Published Paper ID: IJSDR2208058 Registration ID:201229 Published In: Volume 7 Issue 8, August-2022 DOI (Digital Object Identifier): Page No: 433 - 438 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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