Nutraceutical potential of Tasba: acute oral toxicity, antioxidant activity, anti-hyperglycaemic and hypoglycaemic effects of Cassia tora (Fabaceae) leaves

Juliette Koube , Valentin Désiré Guiama , François Eya'ane Meva , Wilfried Corneille Mvondo Ebelle , Bertin Sone Enone

Cassia tora leaves, antioxidant, hypoglycaemia, antihyperglycaemia, nutraceutical potential

Many diseases are associated with dysfunction of glucose metabolism, specifically chronic hyperglycaemia. Cassia tora leaves are used to cook nutritious and tasty sauce, known as Tasba in fulfulde language, consumed in the northern part of Cameroon to lower blood sugar. However, antioxidant activity, hypoglycaemic and anti-hyperglycaemic properties of Cassia tora leaves were not well studied. This study was performed to access the safety, antioxidant activity, as well as hypoglycaemic and anti-hyperglycaemic properties of Cassia tora leaves. For this purpose, we prepare an aqueous extract which contained alkaloids, tannins, flavonoids, anthraquinons, phenols, sterols, coumarins, mucilage and saponins. The median lethal dose (LD50) of extract was greater than 5 g/kg; Cassia tora leaves is devoid of acute oral toxicity. It had free scavenging, reducing and chelating powers, thus acting as type 1 and 2 antioxidants. The percentage of decrease in blood sugar was 72.17% for the positive control and 62.73% for the extract. The inhibition percentage of hyperglycaemia was 73.59% for reference and 64.47% for extract of Cassia tora. Cassia tora leaves appear to be effective in treatment of diabetes, as well as other components of metabolic syndrome associated sugar metabolism and oxidative stress. The results of our research revealed the immense nutraceutical potential of Cassia tora leaves. This suggests that Cassia tora leaves are strongly recommended in the diet of diabetics or people prone to metabolic diseases. However, to take advantage of all the beneficial effects of Cassia tora leaves, it is best to consume them fresh, precisely as juice.

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"Nutraceutical potential of Tasba: acute oral toxicity, antioxidant activity, anti-hyperglycaemic and hypoglycaemic effects of Cassia tora (Fabaceae) leaves ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 6, page no.567 - 575, June-2022, Available :https://ijsdr.org/papers/IJSDR2206091.pdf

Volume 7 Issue 6, June-2022

Pages : 567 - 575

Paper Reg. ID: IJSDR_200663

Published Paper Id: IJSDR2206091

Downloads: 000347078

Research Area: Life Sciences 

Country: Ngaoundéré, Adamawa, Cameroun

Published Paper PDF: https://ijsdr.org/papers/IJSDR2206091

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2206091

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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