Determination of Enantiomeric Purity of Luliconazole by Normal Phase HPLC
Miss. Sayali Shivaji Kumbhar
, Miss. Mansi Vishwanath Bhandwalkar , Prof. Avinash Mahadeo Bhagwat
Luliconazole, Enantiomeric purity, Derivatised, Normal phase, Chiral
The enantiomeric purity of luliconazole, this method was developed to perform with comparative study. This method was based on luliconazole and its isomers can be derivatised with Isomer-II i.e. (-)- (Z)-2-[4(R)-2,4-Dichlorophenyl)- 1,3 -dithiolan-2-ylidene]-2 -(1 H-imidazole- 1 -yl) acetonitrile or Z Isomer. The derivatised compounds can be separated by a chromatography column Phenomenex ceollose – 1 ,250 × 4.6, 5µm, n-Hexane: Ethanol (90:10) used as mobile phase and 1.0 ml/min flow rate at room temperature. Injection volume is 10 µl and run time is 60 min. The detective wavelength is fixed at 215nm. The result indicates the limit of Z isomer complying the quality. [Limit: Z isomer NMT 0.15%], the purity of luliconazole was found to be 99.83%. Repeatability and accuracy are satisfied. This article is generated with aim and review of check analytical chiral purity of luliconazole by HPLC.
"Determination of Enantiomeric Purity of Luliconazole by Normal Phase HPLC", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 5, page no.291 - 293, May-2022, Available :https://ijsdr.org/papers/IJSDR2205055.pdf
Volume 7
Issue 5,
May-2022
Pages : 291 - 293
Paper Reg. ID: IJSDR_200367
Published Paper Id: IJSDR2205055
Downloads: 000347318
Research Area: Pharmacy
Country: Satara, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
