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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Determination of Enantiomeric Purity of Luliconazole by Normal Phase HPLC |
| Authors Name: | Miss. Sayali Shivaji Kumbhar , Miss. Mansi Vishwanath Bhandwalkar , Prof. Avinash Mahadeo Bhagwat |
| Unique Id: | IJSDR2205055 |
| Published In: | Volume 7 Issue 5, May-2022 |
| Abstract: | The enantiomeric purity of luliconazole, this method was developed to perform with comparative study. This method was based on luliconazole and its isomers can be derivatised with Isomer-II i.e. (-)- (Z)-2-[4(R)-2,4-Dichlorophenyl)- 1,3 -dithiolan-2-ylidene]-2 -(1 H-imidazole- 1 -yl) acetonitrile or Z Isomer. The derivatised compounds can be separated by a chromatography column Phenomenex ceollose – 1 ,250 × 4.6, 5µm, n-Hexane: Ethanol (90:10) used as mobile phase and 1.0 ml/min flow rate at room temperature. Injection volume is 10 µl and run time is 60 min. The detective wavelength is fixed at 215nm. The result indicates the limit of Z isomer complying the quality. [Limit: Z isomer NMT 0.15%], the purity of luliconazole was found to be 99.83%. Repeatability and accuracy are satisfied. This article is generated with aim and review of check analytical chiral purity of luliconazole by HPLC. |
| Keywords: | Luliconazole, Enantiomeric purity, Derivatised, Normal phase, Chiral |
| Cite Article: | "Determination of Enantiomeric Purity of Luliconazole by Normal Phase HPLC", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 5, page no.291 - 293, May-2022, Available :http://www.ijsdr.org/papers/IJSDR2205055.pdf |
| Downloads: | 000337215 |
| Publication Details: | Published Paper ID: IJSDR2205055 Registration ID:200367 Published In: Volume 7 Issue 5, May-2022 DOI (Digital Object Identifier): Page No: 291 - 293 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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