SUSCEPTIBILITY OF SLC30A8 rs13266634 POLYMORPHISM IN THE DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS IN SOUTH INDIAN POPULATION

Sheela P , Vijaya Lakshmi B , Sharadha M , Aruna Ramaiah , Jyothy A

Gestational diabetes mellitus, Type 2 diabetes mellitus, Polymerase chain reaction-restriction fragment length polymorphism, SLC30A8, Polymorphism, Insulin C-peptide.

Gestational Diabetes Mellitus (GDM) is one of the major global public health issues in Asia. Various genetic and environmental factors are found to be accountable for the development of GDM. In this back ground SLC30A8 rs13266634 polymorphism is hypothesized to increase the risk of GDM in South-Indian population. The present study aimed to evaluate the association of SLC30A8 rs13266634 polymorphism with risk of GDM. A total of 400 participants, 200 GDM and 200 healthy pregnant women were included in the case-control study. Genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The genotype and allele frequencies were analyzed by applying appropriate statistical methods. An increased frequency of TT genotype and T allele of SLC30A8 rs13266634 polymorphism was observed in GDM women. There was no significant difference in the insulin c-peptide levels between GDM and controls (p=0.2). The minor allele 'T' displayed 1.71 fold (OR=1.71; CI 1.24-2.36, p=0.001) increased risk of GDM. Our study revealed a significant association of SLC30A8 rs13266634 polymorphism with GDM in South-Indian population.

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"SUSCEPTIBILITY OF SLC30A8 rs13266634 POLYMORPHISM IN THE DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS IN SOUTH INDIAN POPULATION", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 2, page no.234 - 238, February-2022, Available :https://ijsdr.org/papers/IJSDR2202039.pdf

Volume 7 Issue 2, February-2022

Pages : 234 - 238

Paper Reg. ID: IJSDR_194014

Published Paper Id: IJSDR2202039

Downloads: 000347221

Research Area: Biological Science

Country: Hyderabad, Telangana, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2202039

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2202039

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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