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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | SUSCEPTIBILITY OF SLC30A8 rs13266634 POLYMORPHISM IN THE DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS IN SOUTH INDIAN POPULATION |
| Authors Name: | Sheela P , Vijaya Lakshmi B , Sharadha M , Aruna Ramaiah , Jyothy A |
| Unique Id: | IJSDR2202039 |
| Published In: | Volume 7 Issue 2, February-2022 |
| Abstract: | Gestational Diabetes Mellitus (GDM) is one of the major global public health issues in Asia. Various genetic and environmental factors are found to be accountable for the development of GDM. In this back ground SLC30A8 rs13266634 polymorphism is hypothesized to increase the risk of GDM in South-Indian population. The present study aimed to evaluate the association of SLC30A8 rs13266634 polymorphism with risk of GDM. A total of 400 participants, 200 GDM and 200 healthy pregnant women were included in the case-control study. Genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The genotype and allele frequencies were analyzed by applying appropriate statistical methods. An increased frequency of TT genotype and T allele of SLC30A8 rs13266634 polymorphism was observed in GDM women. There was no significant difference in the insulin c-peptide levels between GDM and controls (p=0.2). The minor allele 'T' displayed 1.71 fold (OR=1.71; CI 1.24-2.36, p=0.001) increased risk of GDM. Our study revealed a significant association of SLC30A8 rs13266634 polymorphism with GDM in South-Indian population. |
| Keywords: | Gestational diabetes mellitus, Type 2 diabetes mellitus, Polymerase chain reaction-restriction fragment length polymorphism, SLC30A8, Polymorphism, Insulin C-peptide. |
| Cite Article: | "SUSCEPTIBILITY OF SLC30A8 rs13266634 POLYMORPHISM IN THE DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS IN SOUTH INDIAN POPULATION", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 2, page no.234 - 238, February-2022, Available :http://www.ijsdr.org/papers/IJSDR2202039.pdf |
| Downloads: | 000337212 |
| Publication Details: | Published Paper ID: IJSDR2202039 Registration ID:194014 Published In: Volume 7 Issue 2, February-2022 DOI (Digital Object Identifier): Page No: 234 - 238 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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