International Journal of Scientific Development and Research - IJSDR
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Paper Title: Formulation and Evaluation Nanosponges Loaded Hydrogel of Luliconazole
Authors Name: Ms. Ayesha N. Shaikh , Dr. Ashish Y. Pawar
Unique Id: IJSDR2008024
Published In: Volume 5 Issue 8, August-2020
Abstract: The main aim and objective of this project work aimed at development and evaluation of Nanosponges hydrogel of luliconazole and the formulating them as suitable dermatological gel for systemic delivery of drug after topical application, for improved therapeutic effect, better dispersibility, and good storage. Nanosponges is water soluble, this does not mean molecule chemically break up in water but it means that nanosponges particle mix with water and use it as transport fluid. Nanosponges have several advantages over other drug delivery method. Nanosponges using ethyl cellulose as polymer were prepared using PVA as surfactant by Hyper crossed linked method. The effect of different drug: polymer ratio, surfactant concentration, stirring speed, time on physical characteristics of nanosponges were investigated. Optimized batch of nanosponges with the entrapment efficiency were used to formulate the gel with carbopol 940. The prepare gel were evaluated for pH, viscosity, spreadability, In Vitro diffusion study, In vivo skin Irritation test. Nanosponges system are non-toxic, non- irritating, non-allergic, non-mutagenic. Nanosponges gel have large and tremendous effect or potential to serve as topical drug delivery system, better antifungal activity, and storage and stability.
Keywords: Nanosponges, Luliconazole, Topical drug delivery, Hydrogel.
Cite Article: "Formulation and Evaluation Nanosponges Loaded Hydrogel of Luliconazole", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 8, page no.215 - 227, August-2020, Available :http://www.ijsdr.org/papers/IJSDR2008024.pdf
Downloads: 00060116
Publication Details: Published Paper ID: IJSDR2008024
Registration ID:192326
Published In: Volume 5 Issue 8, August-2020
DOI (Digital Object Identifier):
Page No: 215 - 227
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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