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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and Evaluation Nanosponges Loaded Hydrogel of Luliconazole |
| Authors Name: | Ms. Ayesha N. Shaikh , Dr. Ashish Y. Pawar |
| Unique Id: | IJSDR2008024 |
| Published In: | Volume 5 Issue 8, August-2020 |
| Abstract: | The main aim and objective of this project work aimed at development and evaluation of Nanosponges hydrogel of luliconazole and the formulating them as suitable dermatological gel for systemic delivery of drug after topical application, for improved therapeutic effect, better dispersibility, and good storage. Nanosponges is water soluble, this does not mean molecule chemically break up in water but it means that nanosponges particle mix with water and use it as transport fluid. Nanosponges have several advantages over other drug delivery method. Nanosponges using ethyl cellulose as polymer were prepared using PVA as surfactant by Hyper crossed linked method. The effect of different drug: polymer ratio, surfactant concentration, stirring speed, time on physical characteristics of nanosponges were investigated. Optimized batch of nanosponges with the entrapment efficiency were used to formulate the gel with carbopol 940. The prepare gel were evaluated for pH, viscosity, spreadability, In Vitro diffusion study, In vivo skin Irritation test. Nanosponges system are non-toxic, non- irritating, non-allergic, non-mutagenic. Nanosponges gel have large and tremendous effect or potential to serve as topical drug delivery system, better antifungal activity, and storage and stability. |
| Keywords: | Nanosponges, Luliconazole, Topical drug delivery, Hydrogel. |
| Cite Article: | "Formulation and Evaluation Nanosponges Loaded Hydrogel of Luliconazole", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 8, page no.215 - 227, August-2020, Available :http://www.ijsdr.org/papers/IJSDR2008024.pdf |
| Downloads: | 000337212 |
| Publication Details: | Published Paper ID: IJSDR2008024 Registration ID:192326 Published In: Volume 5 Issue 8, August-2020 DOI (Digital Object Identifier): Page No: 215 - 227 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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