FORMULATION AND EVALUATION OF ETRAVIRINE NANOSUSPENSION BY NANO PRECIPITATION METHOD
TIRUPATI RAO BONANGI
, Dr.K. E. V. NAGOJI , Dr.B.V.S.N Murthy , A V S Ksheera Bhavani , Dr.Ch.TarakaRamarao
Etravirine, Poloxamer 407, Sodium lauryl sulfate, Nanoprecipitation technique, SEM, Zeta potential, PSD.
Abstract
The aim of the present work is to develop oral Nanosuspension of Etravirine by Nano Precipitation method using various Stabilizers & Surfactant such as β-cyclodextrin, Soluplus, Poloxamer 407, Polyvinyl alcohol, Sodium lauryl sulfate, Polysorbate 80 Various formulation as well as process parameters were optimized in order to achieve desirable size and saturation solubility. Characterization of the prepared Nanosuspension was done with respect to Drug Content, Percentage yield, Entrapment efficiency, Viscosity, Sedimentation volume, Scanning electron microscopy, Particle’s size, zeta potential, dissolution rate, in-vitro dissolution study. Zeta potential value for the optimized formulation (NS12) was found to -4.49 mv which was found to be within the acceptable limits. Average particle size of Nano suspension of optimized formulations (NS12) which is in ratio with Poloxamer 407 was found to be 500.4 nm. From the invitro studies we can say that formulation NS12 shows best drug release of 98.42±1.27% within 30 minutes whereas all the other formulations didn’t release the drug. The drug release from the Nanosuspension was explained by the using mathematical model equations such as zero order, first order, and equation methods. Based on the regression values it was concluded that the optimized formulation NS12
"FORMULATION AND EVALUATION OF ETRAVIRINE NANOSUSPENSION BY NANO PRECIPITATION METHOD ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.b656-b678, September-2025, Available :https://ijsdr.org/papers/IJSDR2509181.pdf
Volume 10
Issue 9,
September-2025
Pages : b656-b678
Paper Reg. ID: IJSDR_305098
Published Paper Id: IJSDR2509181
Downloads: 00078
Research Area: Pharmacy All
Country: Srikakulam , Andhra Pradesh , India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
