Addressing Recurrent Implantation Failure through Nutritional Support: A review article focusing on the significance of Omega-3 Fatty Acids and Vitamin E – A narrative review

Dr Rashmi Yogish , Dr Amit Nikose , Adarsh Karanth

Recurrent Implantation Failures, Assisted Reproductive Technology, Vitamin E, Omega -3 Fatty Acid

Recurrent Implantation Failure (RIF) is a significant challenge in assisted reproductive technology (ART), which often causes emotional and financial stress for couples. Our review explores the potential benefits of nutritional supplements like Omega-3 fatty acids (OM3FAs) and Vitamin E to improve reproductive success in women with RIF. We gathered evidence from 30 peer-reviewed studies to assess the effects of these nutrients on fertility, endometrial receptivity, and implantation success in both natural conception and ART-assisted cycles. Supplementation with Omega-3 and Vitamin E is generally safe, cost-effective, easily accessible, and has been linked to improved endometrial receptivity and higher implantation rates in women experiencing RIF. OM3FAs may enhance fertility by reducing inflammation, improving perfusion at the implantation site, and enhancing the quality of both oocytes and sperm. Vitamin E has antioxidant properties that contribute to improved endometrial quality and receptivity. Despite promising findings, further studies are necessary to confirm their effectiveness in humans and to develop standardized supplementation protocols for use as adjuncts to support natural and ART-assisted conception. Overall, OM3FAs and Vitamin E represent promising non-invasive options to support reproductive success in women facing recurrent implantation failure.

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"Addressing Recurrent Implantation Failure through Nutritional Support: A review article focusing on the significance of Omega-3 Fatty Acids and Vitamin E – A narrative review", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.b289-b296, September-2025, Available :https://ijsdr.org/papers/IJSDR2509136.pdf

Volume 10 Issue 9, September-2025

Pages : b289-b296

Paper Reg. ID: IJSDR_304967

Published Paper Id: IJSDR2509136

Downloads: 000123

Research Area: Humanities All

Country: Bengaluru, Karnataka , India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2509136

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2509136

DOI: https://doi.org/10.56975/ijsdr.v10i9.304967

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition