Anti-inflammatory and anti-arthritic potential of essential oil from kaempferia galanga Linn. rhizome

Shan P Mohammed , Prof(Dr) Jyoti Harindran , Vishal C S , Anjitha PK

Galanga oil, paw edema,egg albumin, adjuvant arthritis

This research aims to provide pharmacological investigation of Kaempferia galanga rhizome essential oil, specifically focusing on its therapeutic effects across various invitro and in vivo models of inflammation and arthritis. The powdered crude rhizome maintained all the standard parameters . The dried rhizome were subjected to steam distillation to isolate the essential oil and the percent yields of oils obtained in this study were 1.14%w/w. The phytochemical analysis of KGEO were performed using GC-MS and FT-IR. Acute toxicity study, conducted as per OECD 423 guidelines, demonstrated that the oil was safe up to 2000 mg/kg body weight. Evaluation of in vitro anti inflammatory activity by protein denaruration method using egg albumin were conducted, the standard reference drug diclofenac and the plant oil showed concentration dependent inhibition of protein denaturation. However the effect of diclofenac was found to be less when compared with Kaempferia galanga essential oil, which was confirmed with IC50 values ie. IC50 values 82 µg/ml and 62 µg/ml respectively. In in vivo carrageenan induced paw oedema model, oral administration of the essential oil at doses 200 and 400 mg/kg significantly suppressed the paw edema at 2, 3, 4 and 5 h after carrageenan injection in rats. Diclofenac at dose 10mg/kg,p.o significantly suppressed paw edema at 2,3,4 and 5 h after carrageenan administration (p< 0.001).In rats given Freund's adjuvant, oral administration of oil at 200 and 400 mg/kg and prednisolone at 10 mg/kg significantly decreased paw oedema during the second stage of inflammation. On day 13th, 200 mg/kg of oil results in a little decrease in the amount of paw oedema (p<0.05), but 400 mg/kg has an effect that is comparable to that of the standard drug prednisolone at a dose of 10 mg/kg (p<0.01).

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"Anti-inflammatory and anti-arthritic potential of essential oil from kaempferia galanga Linn. rhizome ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 3, page no.a861-a881, March-2025, Available :https://ijsdr.org/papers/IJSDR2503094.pdf

Volume 10 Issue 3, March-2025

Pages : a861-a881

Paper Reg. ID: IJSDR_300985

Published Paper Id: IJSDR2503094

Downloads: 000149

Research Area: Pharmacy All

Country: KOTTAYAM, Kerala, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2503094

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2503094

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

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