Comparative Assessment of Pioglitazone as an Add-On Therapy to Metformin vs. Glimepiride in Type 2 Diabetes: A Retrospective Study

Pritish Kumar Pasayat , Bisakha Tripathy , Prabhudatta Mohapatra

Type 2 Diabetes, Pioglitazone, Glimepiride, Metformin.

The purpose of this retrospective study is to evaluate the clinical results of glimepiride against pioglitazone as a supplement to metformin in individuals with type 2 diabetes. We want to assess the safety and effectiveness of these combinations by examining real-world data in relation to adverse event patterns, weight fluctuations, cardiovascular and renal parameters, and glycemic management. The study will include T2DM patients who have been on a stable treatment regimen with either Metformin and Pioglitazone or Glimepiride and Pioglitazone for at least 6 months. Both Metformin and Pioglitazone and Glimepiride and Pioglitazone combinations significantly improved glycemic parameters over six months. While both groups showed reductions in HbA1c, FBG, and PPBG, the Glimepiride and Pioglitazone group had a slightly greater improvement in fasting glucose levels, whereas the Metformin and Pioglitazone group showed mild weight loss and a greater reduction in systolic blood pressure. To validate these results and evaluate the long-term sustainability of these advantages, more prospective and long-term research is necessary.

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"Comparative Assessment of Pioglitazone as an Add-On Therapy to Metformin vs. Glimepiride in Type 2 Diabetes: A Retrospective Study", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 3, page no.a355-a358, March-2025, Available :https://ijsdr.org/papers/IJSDR2503042.pdf

Volume 10 Issue 3, March-2025

Pages : a355-a358

Paper Reg. ID: IJSDR_300872

Published Paper Id: IJSDR2503042

Downloads: 000320

Research Area: Pharmacy All

Country: Bhubaneswar, Odisha, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2503042

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2503042

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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