Effect of Junglans regia and Nigella sativa on Ethanol Induced Infertility in Male Rats

Omkar kale , V. J. Chaware , V. K. Redasani

Alcohol drinking is one of the major factor for male infertility. In undeveloped and some developing nations, medicinal herbs used to treat male infertility as an alternative to standard. The purpose of this work was to assess the effect of Junglans regia and Nigella sativa on male infertility in wistar rats caused by ethanol. During the course of 14 days, fourty two (42) male wistar rats being randomly assigned to seven groups of six rats each. Group I animals (Control group) were administered with distilled water, Group II animals (Negative or inducer group) were administered with 38% Ethanol at a dose of 10 ml/kg body weight; Group III animals (Positive group) received 38% Ethanol administered with Clomiphene citrate as the reference medication; Groups IV and V animals were administered with 38% Ethanol co-treated with Junglans regia oil at the dose of 5ml/kg and 10ml/kg respectively. Group VI and VII were administered with 38% ethanol co treated with Nigella sativa oil at the dose of 5ml/kg and 10 ml/kg respectively. Testicular histology, sperm parameters and testosterone hormone were assessed. Due to ethanol ingestion, the large fall (p<0.05) in testosterone levels was recorded, ethanol ingestion resulted in a significant rise in sperm abnormalities and a significant reduction (p<0.05) in sperm count, motility, and viability. These findings were consistent with changes seen in the testis during testicular histopathology. Nevertheless, the harmful effects of ethanol on the reproductive organs, sperm viability, motility, abnormality and testosterone level were reversed when animals treated with Junglans regia and Nigella sativa oil.

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"Effect of Junglans regia and Nigella sativa on Ethanol Induced Infertility in Male Rats", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 10, page no.352 - 362, October-2024, Available :https://ijsdr.org/papers/IJSDR2410044.pdf

Volume 9 Issue 10, October-2024

Pages : 352 - 362

Paper Reg. ID: IJSDR_211836

Published Paper Id: IJSDR2410044

Downloads: 000347304

Research Area: Pharmacy

Country: Satara, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2410044

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2410044

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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