PHYTO CHEMICAL SCREENING AND EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF SEBASTIANA CHAMAELEA IN CHEMICALLY INDUCED NEPRO TOXIC RATS

Spandana masannagari

Phyto Chemical Screening, Nephroprotective Activity, Ethanolic Extract, Leaves, Sebastiana Chamaelea

The plant contains alkaloids, Glycosides, Flavonoids, Tanins Proteins, Amino Acids. The renal antioxidant status, such as SOD, CAT, GPx activities, and reduced GSH concentration are significantly decreased in the cisplatin treated group of animals compared to the control group. The declined antioxidant status partially explains the mechanism of nephrotoxicity induced by cisplatin. The histopathological evaluation of the kidney preparations in treatment group also revealed a decreased cisplatin-induced tubular necrosis. Cisplatin-induced renal damage is associated with increased renal vascular resistance and histopathological damage to proximal tubular cells. On the other hand, an increase in GSH levels in the renal tissue indicates that pretreatment with EESC was due to oxidative stress. The effects of EESC on cellular GSH may be due to antioxidant effects. The treatment with EESC prevented the lipid peroxidation by enhancing the renal CAT, SOD and GPx activities. it was shown that cisplatin treatment induced renal damage and pretreatment with ethanolic extract of Sebastiana chamaelea (EESC) provided protective effect against this cisplatin-induced nephrotoxicity. However, before concluding a potential usefulness of ethanolic extract of Sebastiana chamaelea (EESC) as adjunct to the cisplatin therapy, further clinical investigation is needed.

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"PHYTO CHEMICAL SCREENING AND EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF SEBASTIANA CHAMAELEA IN CHEMICALLY INDUCED NEPRO TOXIC RATS ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 10, page no.85 - 93, October-2024, Available :https://ijsdr.org/papers/IJSDR2410010.pdf

Volume 9 Issue 10, October-2024

Pages : 85 - 93

Paper Reg. ID: IJSDR_212525

Published Paper Id: IJSDR2410010

Downloads: 000347261

Research Area: Pharmacy

Country: Hyderabad, Telangana, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2410010

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2410010

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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