A comparative observational study on desidustat to erythropoiesis-stimulating agent for anemia management in dialysis-dependent patients

Alladi Keerthana , Manduguloju Snehika, M. Sreelekha , G. Susmitha, Srikanth Gundlapalli , Sujeeth Bande, A.V Kishore Babu , A. Srinivas Rao

Chronic Kidney Disease, Anemia, Dialysis, Erythropoiesis-stimulating Agent, HIF (hypoxia-inducible factor)-PH (prolyl hydroxylase) inhibitor, Desidustat

Background: Anaemia is the most common complication observed as renal disease worsens. Conventionally used recombinant human erythropoietin (rHuEPO) agents have significantly altered how anemia is treated in CKD patients. A novel drug, desidustat, which is a HIF (hypoxia-inducible factor)-PH (prolyl hydroxylase) inhibitor, has been approved recently in India for the management of anemia in dialysis-dependent and dialysis-non-dependent patients. Aims and Objectives: The key objective of this research is to compare Desidustat and ESAs' effectiveness in treating anemia in individuals who are reliant on dialysis. Materials and Methods: This study was conducted at the Asian Institute Of Nephrology and Urology, Banjara Hills, for 6 months. A total of 64 patients were included. Informed consent was obtained from all the subjects who had undergone dialysis at least twice a week in the hospital. Results: The time taken and change in mean hemoglobin values were contrasted with an unpaired t-test, and the p-value was found to be >0.05, not statistically significant. There were very mild adverse events observed in both treatment groups, which were usually relieved by symptomatic treatment. Conclusion: This study identifies the non-inferiority of desidustat over erythropoiesis-stimulating agents in the treatment of anemia in dialysis-dependent chronic kidney disease patients. Patients on desidustat attained normal hemoglobin levels within a shorter time frame and maintained this range for a longer duration as compared to ESAs. There were no severe adverse events observed in either of the groups.

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"A comparative observational study on desidustat to erythropoiesis-stimulating agent for anemia management in dialysis-dependent patients", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 5, page no.933 - 942, May-2024, Available :https://ijsdr.org/papers/IJSDR2405125.pdf

Volume 9 Issue 5, May-2024

Pages : 933 - 942

Paper Reg. ID: IJSDR_211425

Published Paper Id: IJSDR2405125

Downloads: 000347642

Research Area: Medical Science

Country: Hyderabad, Telangana, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2405125

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2405125

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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