A Review on Bilayer tablet for Hypertension and Diabetes

Nilesh P. Musmade , Rahul S. Kamble , Dr. V.M. Satpute , Ghodke S.R. , Navgire Pravin

Hypertension, Diabetes, Bilayer Tablet, Compression, Consolidation.

The bilayer tablet is a new technology for a successful improvement of controlled release method alongside numerous functions to ensure successful drug transport. Bilayer drugs encompass layers, which are a gradual-release layer and an instantaneous-release layer. In addition to stepped forward positive technology to overcome the shortcomings of single-layer tablet. Bi-layer tablet formulations have been required due to separate collectively incompatible lively pharmaceutical ingredients (APIs). The bilayer tablet cloth consists of both compressibility and consolidation. The cutting-edge paintings specialize in the development of a double-layer pill of empagliflozin and aliskiren inside the treatment of diabetes and hypertension. The release of aliskiren and empagliflozin was controlled with the aid of their method into a right way and sustained release layer. both layers had been prepared by moist granulation. The compatibility of polymers and excipients in conjunction with natural drugs became evaluated the use of FTIR research. tablets had been prepared and parameters earlier than and after compression, in vitro dissolution trying out, launch rate kinetics and stability studies had been evaluated. The feet-IR spectrum confirms the absence of chemical interplay among the drug and the polymers. The parameters before and after compression have been observed to be within perfect limits. For the bilayer tablet, one system of each layer changed into decided on based totally on the in vitro dissolution profile records. The cause for this constant mixture is the joint administration of drugs with extraordinary mechanisms of movement, a reduction in dosing frequency and a boom in patient compliance.

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"A Review on Bilayer tablet for Hypertension and Diabetes", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 5, page no.279 - 283, May-2024, Available :https://ijsdr.org/papers/IJSDR2405036.pdf

Volume 9 Issue 5, May-2024

Pages : 279 - 283

Paper Reg. ID: IJSDR_211193

Published Paper Id: IJSDR2405036

Downloads: 000347369

Research Area: Pharmacy

Country: Ahmednagar, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2405036

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2405036

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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