Development and Evaluation of Psidium guajava Loaded Herbal Nail Lacquer for the Treatment of Onychomycosis Fungal Infection

Navneet Mehan , Ritika Chauhan , Manit Singh , Himanshu Sharma , Suman Anjali, Lalit Sharma

Keywords: Psidium guajava, Nail lacquer, Onychomycosis, fungus, Tineaunguium.

ABSTRACT A well-known nail fungus known by the names Dermatophytes onychomycosis and Tineaunguium is onychomycosis. The pathogens that cause onychomycosis are dermatophytes, Candida, and non-dermatophytic molds. This study has produced a natural nail lacquer that is antifungal. The objective of this study was to reduce the course of treatment and deliver a consistent release of Psidium guajava over an extended period of time—up to 24 hours. It was anticipated that this would increase patient cooperation as well as potency. The nail lacquer preparation was created through straightforward mixing and its non-volatile content was examined. Functional group identification, drug content estimation, gloss, viscosity, drying time, drug diffusion investigations, and anti-fungal studies are among the applications for FTIR analysis. The nail lacquer with the best non-volatile content, drug release, drug content estimation, and zone of inhibition was made up of 4% Psidium guajava, 8% Eudragit RL-100, 2% ethyl cellulose, 2% ethyl acetate, 0.8% Dibutylphthalate, 10% salicylic acid, and 0.4% acetone out of all the formulations. It is possible that the medication release continued for up to 24 hours, and 72.25% of the drug was delivered overall. Phenols and flavonoids were detected in the acetone extract of the Psidium guajava-loaded nail lacquer, according to FTIR analysis. An expedited stability assessment of the specially developed formulation F4 was carried out for one month at 42 ± 2 °C in accordance with ICH rules, revealing that no significant alteration in the original features was observed. Thus, it follows that antifungal nail lacquer is among the ground-breaking drugs that could revolutionize the pharmaceutical and medical fields.

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"Development and Evaluation of Psidium guajava Loaded Herbal Nail Lacquer for the Treatment of Onychomycosis Fungal Infection", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 5, page no.212 - 221, May-2024, Available :https://ijsdr.org/papers/IJSDR2405028.pdf

Volume 9 Issue 5, May-2024

Pages : 212 - 221

Paper Reg. ID: IJSDR_211251

Published Paper Id: IJSDR2405028

Downloads: 000347469

Research Area: Pharmacy

Country: Yamunanagar, Haryana, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2405028

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2405028

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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