CLINICAL PROFILE MEDICATION ADHERENCE AND ADVERSE DRUG REACTIONS OF ANTI-TB DRUGS IN DEPARTMENT OF PULMONARY MEDICINE IN A TERTIARY CARE HOSPITAL
Dr. S. RAJESH RAJA
, S. ZUWERIYA SULTHANA , G.E. LIKITHA , P. ASMA
Naranjo Adverse Drug Reaction Probability Scale, Morisky Medication Adherence scale.
INTRODUCTION Tuberculosis is a chronic infections disease caused by Mycobacterium tuberculosis and occasionally by Mycobacterium bovis and Mycobacterium africanum. It particularly affects the lung which is called pulmonary TB. There is increased incidence of tuberculosis in HIV positive patients but it can affect other sites as well. TB accounts for more than 10 million cases and 1.3 million deaths. Adherence to TB drugs is critical in achieving successful treatment outcomes controlling the spread and preventing the development of drug resistance non-adherence to treatment refers to a patient's inability or refusal to take TB medications as prescribed by a health professional. Non-adherence to Antituberculosis treatment adversely affects treatment success rate. It increases morbid and mortality. Also, it contributes significantly to the development of drug resistance. AIMS & OBJECTIVES To assess the Clinical Profile, Medication Adherence and Adverse Drug Reactions of Anti Tubercular Drugs in Government General Hospital. OBJECTIVES OF THE STUDY The key objectives of the study include To assess the clinical profile of TB patients To determine the medication adherence To determine the adverse drug reactions of anti-tubercular drugs. METHODOLOGY: It is a prospective observational study to be conducted in Government General Hospital Kurnool district in the department of pulmonary medicine. RESULTS & DISCUSSION: In our present study, 70(57.37%) were males and 52 (42.62%) were females. This study was similar to the study conducted by maheen Humayun et al29 where males were 58.5 & females were 41.5. In our present study of social habits males with smoking are 40(32.7%) and alcoholic are 33(27%). Whereas females with smoking are 5(4.09%) and alcoholic are 4(3.37) and 39(31.9%) patients are diabetic, 44(36%) patients have hypertension, 19(15.5%) patients have thyroid, 16(13.1%) patients have renal problems, 17(13.9%) patients have HIV and 15(12.2%) patients have cardiac problems. The common clinical manifestation is cough with sputum (78.5%) followed with weight loss of (63.49%), loss of appetite (61.1%), fever with night sweats (56.34%), chest pain (44.44%), shortness of breath (46.35%) and blood with sputum (14.28%). In our study most of the patients are non-adhere (31.1%) to the TB medications which may be due to negligence (inadequate knowledge) 25.19% followed by adverse drug reactions (22.13%), below poverty (14.28%) and Physiatric problems (6.55%). CONCLUSION: The present study was conducted to study the clinical manifestations, medication adherence and adverse drug reactions of TB medications. Tuberculosis has become a public health crisis. In the current study, the sample size was 122; most of them are males constituting 57.37%. The mean age of the study subjects was 65.5 years. Majority of patients was suffering with TB in the age of 50-80 years. Joint pains were the most common ADR constituting 43.41% whereas nephrotoxicity was the least ADR constituting 4.91%. Negligence (inadequate knowledge) was the most common associated barrier to TB medication constituting 25.19% whereas the psychiatric problem (6.555) was the least associated barrier.
"CLINICAL PROFILE MEDICATION ADHERENCE AND ADVERSE DRUG REACTIONS OF ANTI-TB DRUGS IN DEPARTMENT OF PULMONARY MEDICINE IN A TERTIARY CARE HOSPITAL", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 5, page no.198 - 211, May-2024, Available :https://ijsdr.org/papers/IJSDR2405027.pdf
Volume 9
Issue 5,
May-2024
Pages : 198 - 211
Paper Reg. ID: IJSDR_211213
Published Paper Id: IJSDR2405027
Downloads: 000347339
Research Area: Pharmacy
Country: KURNOOL, ANDHRA PRADESH, INDIA
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
