FORMULATIONS AND EVALUATION OF NISOLDIPINE SUSTAINED RELEASE MATRIX TABLETS

Gangavarapu Nadia Psalms , Dr SRINIVASRAO MANDE , LALITHA REPUDI , Dr KUMARASWAMY GANDLA , Sravanthi Gandu

: Nisoldipine; sustained release matrix tablets; Stability studies; formulate and evaluate

The Present study was undertaken with an aim to formulate and evaluate Nisoldipine sustained release matrix tablets, a centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. Preformulation studies were carried and results were found to be satisfactory. The compatible excipients were selected for the formulation development.Experiment was performed by using both dry and wet granulation techniques based on the flow properties of API. In order to increase the flow property of the tablets, wet granulation was chosen for further formulation and found to be satisfactory. During development of formula, in-process tests such as bulk density, tapped density, Carr’s index, Hausner’s ratio and angle of repose were evaluated for granules and hardness, friability, weight variation, thickness and disintegration were evaluated for the core tablets. Core tablets were coated with coating suspension.Finished products were evaluated for hardness, friability, weight variation, thickness, disintegration, dissolution and drug content.The developed trials were tested for in-vitro dissolution profile and compared with the reference product Carisoma. Stability studies performed at 45°C /75% RH, 25oC /60% RH for 2 months. Stability samples were evaluated initially and after 2 months. The results were compared with the pre-determined specifications. All the results were found to be satisfactory.

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"FORMULATIONS AND EVALUATION OF NISOLDIPINE SUSTAINED RELEASE MATRIX TABLETS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 5, page no.151 - 172, May-2024, Available :https://ijsdr.org/papers/IJSDR2405021.pdf

Volume 9 Issue 5, May-2024

Pages : 151 - 172

Paper Reg. ID: IJSDR_211208

Published Paper Id: IJSDR2405021

Downloads: 000347490

Research Area: Pharmacy

Country: Hyderbabad, Telangana, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2405021

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2405021

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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